{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:02:45Z","timestamp":1792008165425,"version":"4.4.0"},"reference-count":257,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Colorectal cancer (CRC) development and progression, one of the most common cancers globally, is supported by specific mechanisms to escape cell death despite chemotherapy, including cellular autophagy. Autophagy is an evolutionarily highly conserved degradation pathway involved in a variety of cellular processes, such as the maintenance of cellular homeostasis and clearance of foreign bodies, and its imbalance is associated with many diseases. However, the role of autophagy in CRC progression remains controversial, as it has a dual function, affecting either cell death or survival, and is associated with cellular senescence in tumor therapy. Indeed, numerous data have been presented that autophagy in cancers serves as an alternative to cell apoptosis when the latter is ineffective or in apoptosis\u2010resistant cells, which is why it is also referred to as programmed cell death type II. Curcumin, one of the active constituents of\n                    <jats:italic>Curcuma longa<\/jats:italic>\n                    , has great potential to combat CRC by influencing various cellular signaling pathways and epigenetic regulation in a safe and cost\u2010effective approach. This review discusses the efficacy of curcumin against CRC in vitro and in vivo, particularly its modulation of autophagy and apoptosis in various cellular pathways. While clinical studies have assessed the potential of curcumin in cancer prevention and treatment, none have specifically examined its role in autophagy. Nonetheless, we offer an overview of potential correlations to support the use of this polyphenol as a prophylactic or co\u2010therapeutic agent in CRC.\n                  <\/jats:p>","DOI":"10.1002\/ptr.8220","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T05:27:49Z","timestamp":1714714069000},"page":"3525-3551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Curcumin and its anti\u2010colorectal cancer potential: From mechanisms of action to autophagy"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8101-2828","authenticated-orcid":false,"given":"Aranka","family":"Brockmueller","sequence":"first","affiliation":[{"name":"Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine Ludwig\u2010Maximilians\u2010University Munich  Munich 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