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One group of bioactive phytochemicals that has gained significant attention recently is dietary polyphenols. These compounds are commonly found in a variety of fruits, vegetables, spices, nuts, drinks, legumes, and grains. Despite their incredible therapeutic properties, one challenge with polyphenols is their poor water solubility, stability, and bioavailability. This means that they are not easily absorbed by the body when consumed in essential diets. Because of structural complexity, polyphenols with high molecular weight cannot be absorbed in the small intestine and after arriving in the colon, they are metabolized by gut microbiota. However, researchers are constantly working on finding solutions to enhance the bioavailability and absorption of these compounds. This study aims to address this issue by applying nanotechnology approaches to overcome the challenges of the therapeutic application of dietary polyphenols. This combination of nanotechnology and phytochemicals could cause a completely new field called nanophytomedicine or herbal nanomedicine.<\/jats:p>","DOI":"10.1002\/ptr.8230","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T05:54:14Z","timestamp":1715320454000},"page":"3607-3644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Nanophytomedicine: A promising practical approach in phytotherapy"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4629-7159","authenticated-orcid":false,"given":"Hadi","family":"Sardarabadi","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, School of Medicine Qom University of Medical Sciences  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hasan","family":"Darvishi","sequence":"additional","affiliation":[{"name":"Nanobiotechnology Research 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