{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T06:38:30Z","timestamp":1769236710153,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202101ZYTS106"],"award-info":[{"award-number":["YDZJ202101ZYTS106"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20220562KJ"],"award-info":[{"award-number":["JJKH20220562KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["D18012"],"award-info":[{"award-number":["D18012"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973555"],"award-info":[{"award-number":["81973555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Environmental pollution, virus infection, allergens, and other factors may cause respiratory disease, which could be improved by dietary therapy. <jats:italic>Allium<\/jats:italic> species are common daily food seasoning and have high nutritional and medical value. Diallyl disulfide (DADS) is the major volatile oil compound of <jats:italic>Allium<\/jats:italic> species. The present study aims to explore the preventive effect and potential mechanism of DADS on pulmonary fibrosis. C57BL\/6J mice were intratracheally injected with bleomycin (BLM) to establish pulmonary fibrosis and then administrated with DADS. Primary lung fibroblasts or A549 were stimulated with BLM, followed by DADS, farnesoid X receptor (FXR) agonist (GW4064), yes\u2010associated protein 1 (YAP1) inhibitor (verteporfin), or silencing of FXR and YAP1. In BLM\u2010stimulated mice, DADS significantly ameliorated histopathological changes and interleukin\u20101\u03b2 levels in bronchoalveolar lavage fluid. DADS decreased fibrosis markers, HIF\u20101\u03b1, inflammatory cytokines, and epithelial\u2010mesenchymal transition in pulmonary mice and activated fibroblasts. DADS significantly enhanced FXR expression and inhibited YAP1 activation, which functions as GW4064 and verteporfin. A deficiency of FXR or YAP1 could result in the increase of these two protein expressions, respectively. DADS ameliorated extracellular matrix deposition, hypoxia, epithelial\u2010mesenchymal transition, and inflammation in FXR or YAP1 knockdown A549. Taken together, targeting the crosstalk of FXR and YAP1 might be the potential mechanism for DADS against pulmonary fibrosis. DADS can serve as a potential candidate or dietary nutraceutical supplement for the treatment of pulmonary fibrosis.<\/jats:p>","DOI":"10.1002\/ptr.8268","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T07:49:10Z","timestamp":1718178550000},"page":"4009-4021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diallyl disulfide, the bioactive component of <i>Allium<\/i> species, ameliorates pulmonary fibrosis by mediating the crosstalk of farnesoid X receptor and yes\u2010associated protein 1 signaling pathway"],"prefix":"10.1002","volume":"38","author":[{"given":"Jia\u2010yi","family":"Dou","sequence":"first","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain (Ministry of Education), Key Laboratory for Traditional Chinese Korean Medicine Research (State Ethnic Affairs), College of Pharmacy Yanbian University  Yanji China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010yu","family":"Cui","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain (Ministry of Education), Key Laboratory for Traditional Chinese Korean Medicine Research (State Ethnic Affairs), College of Pharmacy Yanbian University  Yanji China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010yan","family":"Xuan","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Josai University  Sakado Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain (Ministry of Education), Key Laboratory for Traditional Chinese Korean Medicine Research (State Ethnic Affairs), College of Pharmacy Yanbian University  Yanji China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao\u2010Xu","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain (Ministry of Education), Key Laboratory for Traditional Chinese Korean Medicine Research (State Ethnic Affairs), College of Pharmacy Yanbian University  Yanji China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010hua","family":"Lian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain (Ministry of Education), Key Laboratory for Traditional Chinese Korean Medicine Research (State Ethnic Affairs), College of Pharmacy Yanbian University  Yanji China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao\u2010zhen","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Chinese Traditional Medicine, Medical College Yanbian University  Yanji China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6221-4309","authenticated-orcid":false,"given":"Ji\u2010xing","family":"Nan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain (Ministry of Education), Key Laboratory for Traditional Chinese Korean Medicine Research (State Ethnic Affairs), College of Pharmacy Yanbian University  Yanji China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain (Ministry of Education), Key Laboratory for Traditional Chinese Korean Medicine Research (State Ethnic Affairs), College of Pharmacy Yanbian University  Yanji China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.10.030"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-021-04213-2"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05594-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2021.102053"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0250-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2017.01.010"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.114042"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2021.136"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13466"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005189"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00185114"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12977"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24541"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900325R"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.05.039"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108327"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7113-8_2"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34249"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0834-8"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5103626"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105635"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2020.12.018"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201900162"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9283204"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2048-9"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.02.005"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9137251"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2011-0042"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.8268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T18:10:24Z","timestamp":1723572624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.8268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/ptr.8268"],"URL":"https:\/\/doi.org\/10.1002\/ptr.8268","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,12]]},"assertion":[{"value":"2023-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}