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We conducted a systematic search of the PubMed, SCOPUS, and Web of Science databases for randomized clinical trials and identified 15 studies (<jats:italic>n<\/jats:italic>\u2009=\u2009835 subjects). We used random\u2010effects models with DerSimonian\u2010Laird methods to analyze the serum levels of alanine aminotransferase and aspartate aminotransferase enzymes. Our results indicate that curcumin did not affect serum alanine aminotransferase, but it did reduce aspartate aminotransferase levels. Notably, both outcomes showed high heterogeneity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Subgroup analysis revealed that adding piperine to curcumin did not benefit aminotransferase levels in NAFLD patients. Additionally, we found a negative correlation between the duration of the intervention and the relative (mg\/kg\/day) curcumin dose with the reduction in liver aminotransferases. In summary, the sources of heterogeneity identified in our study are likely attributed to the duration of the intervention and the relative dose of curcumin. Consequently, longer trials utilizing high doses of curcumin could diminish the positive impact of curcumin in reducing serum levels of aminotransferases in patients with NAFLD.<\/jats:p>","DOI":"10.1002\/ptr.8274","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T06:40:30Z","timestamp":1720161630000},"page":"4261-4271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Does curcumin improve liver enzymes levels in <scp>nonalcoholic fatty liver disease<\/scp>? 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