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This condition leads to increased body fat and reduced daily activity, contributing to severe health issues and a lower quality of life among the elderly. Recognized in the ICD\u201010\u2010CM only in 2016, sarcopenia lacks definitive treatment options despite its growing prevalence and substantial social and economic implications. Given the aging global population, addressing sarcopenia has become increasingly relevant and necessary. The primary causes include aging, cachexia, diabetes, and nutritional deficiencies, leading to imbalances in protein synthesis and degradation, mitochondrial dysfunction, and hormonal changes. Exercise remains the most effective intervention, but it is often impractical for individuals with limited mobility, and pharmacological options such as anabolic steroids and myostatin inhibitors are not FDA\u2010approved and are still under investigation. This review is crucial as it examines the potential of natural products as a novel treatment strategy for sarcopenia, targeting multiple mechanisms involved in its pathogenesis. By exploring natural products' multi\u2010targeted effects, this study aims to provide innovative and practical solutions for sarcopenia management. Therefore, this review indicates significant improvements in muscle mass and function with the use of specific natural compounds, suggesting promising alternatives for those unable to engage in regular physical activity.<\/jats:p>","DOI":"10.1002\/ptr.8301","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T05:24:43Z","timestamp":1722835483000},"page":"5033-5051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A novel treatment strategy targeting cellular pathways with natural products to alleviate sarcopenia"],"prefix":"10.1002","volume":"38","author":[{"given":"Da Hee","family":"Lee","sequence":"first","affiliation":[{"name":"College of Korean Medicine Woosuk University  Jeonju\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Korean Medicine Woosuk University  Jeonju\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabsik","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Korean Medicine Woosuk University  Jeonju\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Korean Medicine Woosuk University  Jeonju\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Uk","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Korean Medicine Woosuk University  Jeonju\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Han","family":"Yook","sequence":"additional","affiliation":[{"name":"College of Korean Medicine Woosuk University  Jeonju\u2010si Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7740-8627","authenticated-orcid":false,"given":"Jun Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Korean Medicine Woosuk University  Jeonju\u2010si Republic of Korea"},{"name":"Da Capo Co., Ltd.  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