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Owing to the putative metabolic benefits of curcumin\u2013piperine combination, we explored the efficacy of this combination in improving cardiometabolic indices of patients with T2DM and hypertriglyceridemia. In this double\u2010blind clinical trial, 72 patients with T2DM and hypertriglyceridemia were randomized to receive either a tablet containing 500\u2009mg of curcuminoids plus 5\u2009mg of piperine, or a matched placebo for 12\u2009weeks. Anthropometric indices, blood pressure, glycemic indices, lipid profile, C\u2010reactive protein (CRP), quality of life, and mood were evaluated at baseline and end of the study. After 12\u2009weeks of intervention, the levels of triglycerides (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u20090.001) and fasting blood glucose (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u20090.004) were significantly reduced in the curcumin\u2010piperine compared with the placebo group. CRP levels were marginally reduced in the curcumin\u2013piperine compared with the placebo group (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u20090.081). In addition, energy\/fatigue significantly increased in the curcumin\u2013piperine group compared to the control group (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u20090.024). However, between\u2010group comparisons showed no significant change in other parameters, including anthropometric indices (waist circumference and body mass index (BMI)), biochemical parameters (low\u2010density lipoprotein (LDL\u2010c), high\u2010density lipoprotein (HDL\u2010c), and insulin), HOMA\u2010IR, blood pressure, quality of life, and DASS\u201021 items between the studied groups (<jats:italic>p<\/jats:italic>\u2010value &gt;0.05). The current study showed that curcumin\u2013piperine supplementation can improve serum CRP, triglycerides, and glucose concentrations in patients with T2DM and hypertriglyceridemia.<\/jats:p>","DOI":"10.1002\/ptr.8304","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T03:04:46Z","timestamp":1724295886000},"page":"5150-5161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The effect of curcumin\u2010piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in patients with type 2 diabetes mellitus and hypertriglyceridemia"],"prefix":"10.1002","volume":"38","author":[{"given":"Hanie","family":"Hosseini","sequence":"first","affiliation":[{"name":"Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5861-6129","authenticated-orcid":false,"given":"Mohammad","family":"Bagherniya","sequence":"additional","affiliation":[{"name":"Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Anesthesia and Critical Care Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences Saveetha University  Chennai India"},{"name":"Applied Biomedical Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijan","family":"Iraj","sequence":"additional","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Majeed","sequence":"additional","affiliation":[{"name":"Sami\u2010Sabinsa Group Limited  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1194-9687","authenticated-orcid":false,"given":"Gholamreza","family":"Askari","sequence":"additional","affiliation":[{"name":"Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Anesthesia and Critical Care Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7274"},{"issue":"3","key":"e_1_2_13_3_1","first-page":"217","article-title":"Effect of turmeric on body measurement indices, glycemic condition, and lipid profile in hyperlipidemic patients with type 2 diabetes","volume":"8","author":"Adab Z.","year":"2013","journal-title":"Iranian Journal of Nutrition Sciences & Food Technology"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6328"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106414"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00868-7"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-28012-2_22"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06375-w"},{"issue":"1","key":"e_1_2_13_9_1","first-page":"258","article-title":"Biochemical basis of enhanced drug bioavailability by piperine: Evidence that piperine is a potent inhibitor of drug metabolism","volume":"232","author":"Atal C. 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