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The available evidence showed promising hypoglycemic effects of the nutraceuticals reviewed both for their efficacy and safety profile. However, contradictory results as regard the efficacy of some supplements such as <jats:italic>Allium sativum<\/jats:italic>, <jats:italic>Juglans regia<\/jats:italic>, and <jats:italic>Lycium barbarum<\/jats:italic> on glucose homeostasis have emerged from some clinical studies. Other nutraceuticals including <jats:italic>Aloe vera<\/jats:italic>, <jats:italic>Amorphophallus Konjac<\/jats:italic>, <jats:italic>Bauhinia forficata<\/jats:italic>, <jats:italic>Coccinia<\/jats:italic>, <jats:italic>Ganoderma lucidum<\/jats:italic>, <jats:italic>Ipomoea batatas<\/jats:italic>, and <jats:italic>Lupinus mutabilis<\/jats:italic> require larger and long\u2010term studies rigorously designed to confirm their hypoglycemic effects due to the scarce data available and the poor quality of clinical trials. Further studies are also required for <jats:italic>Cinnamomum<\/jats:italic>, <jats:italic>Cynara scolymus<\/jats:italic>, <jats:italic>Momordica charantia<\/jats:italic>, <jats:italic>Olea europaea<\/jats:italic>, and <jats:italic>Opuntia streptacantha<\/jats:italic>. Moreover, well\u2010designed large and long\u2010term clinical trials including the use of standardized nutraceutical preparations are necessary for <jats:italic>Phaseolus vulgaris<\/jats:italic> and <jats:italic>Vaccinium myrtillus<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ptr.8312","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T05:13:46Z","timestamp":1728018826000},"page":"5490-5532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature. 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