{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:18:18Z","timestamp":1778494698077,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,10,24]],"date-time":"2001-10-24T00:00:00Z","timestamp":1003881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The antiviral effects of aqueous extracts of <jats:italic>Terminalis chebula<\/jats:italic> Retz., <jats:italic>Sanguisorba officinalis<\/jats:italic> L., <jats:italic>Rubus coreanus<\/jats:italic> Miq. and <jats:italic>Rheum palmatum<\/jats:italic> L. were examined by a cell culture system using a hepatitis B virus (HBV) producing cell line, HepG2 2.2.15. The extracts were assayed for the inhibition of HBV multiplication by measurement of HBV DNA and surface antigen (HBsAg) levels in the extracellular medium of HepG2 2.2.15 cells after an 8\u2010day treatment. All extracts decreased the levels of extracellular HBV virion DNA at concentrations ranging from 64 to 128\u2005\u03bcg\/mL and inhibited the secretion of HBsAg dose dependently. Of the four tested plants, <jats:italic>Terminalis chebula<\/jats:italic> exhibited the most prominent anti\u2010HBV activities. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.832","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T16:32:22Z","timestamp":1030293142000},"page":"718-720","source":"Crossref","is-referenced-by-count":75,"title":["Antiviral activities of extracts isolated from <i>Terminalis chebula<\/i> retz., <i>Sanguisorba officinalis<\/i> L., <i>Rubus coreanus<\/i> miq. and <i>Rheum palmatum<\/i> L. against hepatitis B virus"],"prefix":"10.1002","volume":"15","author":[{"given":"Tae Gyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seog Youn","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Kyung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Hye","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Euna","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Mee","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,10,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.19.6909"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650090609"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199705)11:3<179::AID-PTR50>3.0.CO;2-F"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01973705"},{"key":"e_1_2_1_6_1","first-page":"70","article-title":"Cloning and expression of hepatitis B virus surface antigen gene","volume":"17","author":"Kim Y","year":"1984","journal-title":"Kor Biochem J"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(92)90056-B"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80277-0"},{"key":"e_1_2_1_9_1","series-title":"Molecular Cloning: A Laboratory Manual","first-page":"9.31","author":"Sambrook J","year":"1989"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.4.1005"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.832","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T09:58:37Z","timestamp":1700301517000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,24]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1002\/ptr.832"],"URL":"https:\/\/doi.org\/10.1002\/ptr.832","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,10,24]]}}}