{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:29:28Z","timestamp":1791491368024,"version":"4.3.4"},"reference-count":73,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Metabolic syndrome (MetS) is an ever\u2010evolving set of diseases that poses a serious health risk in many countries worldwide. Existing evidence illustrates that individuals with MetS have a 30%\u201340% higher chance of acquiring type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), or both. This study was undertaken to uncover the regulatory role of natural organosulfur compounds (OSCs),\n                    <jats:italic>S<\/jats:italic>\n                    \u2010allyl\u2010L\u2010cysteine (SAC), and\n                    <jats:italic>S<\/jats:italic>\n                    \u2010ethyl\u2010L\u2010cysteine (SEC), in targeting high carbohydrate high fat (HCHF)\u2010diet\u2010induced MetS\u2010associated risk management. Our findings suggested that SAC and SEC ameliorated HCHF\u2010diet\u2010induced diabetic profiles, plasma lipid and lipoprotein level, liver function, oxidative\u2010stress, inflammatory cytokines, and chemokines including monocyte chemoattractant protein\u20101 (MCP\u20101), lipid peroxidation, plasma proprotein convertase subtilisin\/kexin type\u20109 (PCSK\u20109), and high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP). Moreover, the assessment of the hepatic mRNA expression of the key genes involved in cholesterol homeostasis depicted that SAC and SEC downregulated the PCSK\u20109 mRNA expression via targeting the expression of HNF\u20101\u03b1, a transcriptional activator of PCSK\u20109. On the other hand, the LDL\u2010receptor (LDL\u2010R) expression was upregulated through the activation of its transcriptional regulator sterol regulatory element binding protein\u20102 (SREBP\u20102). In addition, the activity and the mRNA expression of 3\u2010hydroxy\u20103\u2010methylglutaryl coenzyme\u2010A reductases (HMG\u2010R) and peroxisome proliferator\u2010activated receptors (PPARs) were also improved by the treatment of SAC and SEC. We concluded that SAC and SEC can protect against MetS via improving the lipid and lipoprotein content, glycemic indices, hepatic function, targeting the inflammatory cascades, and oxidative imbalance, regulation of the mRNA expression of PCSK\u20109, LDL\u2010R, SREBP\u20102, HNF\u20101\u03b1, PPARs, and inflammatory biomarkers.\n                  <\/jats:p>","DOI":"10.1002\/ptr.8323","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T07:06:46Z","timestamp":1725347206000},"page":"5413-5433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Organosulfur Compounds,\n                    <i>S<\/i>\n                    \u2010Allyl\u2010L\u2010Cysteine and\n                    <i>S<\/i>\n                    \u2010Ethyl\u2010L\u2010Cysteine, Target\n                    <scp>PCSK<\/scp>\n                    \u20109\/\n                    <scp>LDL<\/scp>\n                    \u2010R\u2010Axis to Ameliorate Cardiovascular, Hepatic, and Metabolic Changes in High Carbohydrate and High Fat Diet\u2010Induced Metabolic Syndrome in Rats"],"prefix":"10.1002","volume":"39","author":[{"given":"Parvej","family":"Ahmad","sequence":"first","affiliation":[{"name":"Integral Information &amp; Research Center (IIRC\u20105), Clinical Biochemistry &amp; Natural Product Research Lab, Department of Biosciences Integral University  Lucknow Uttar Pradesh India"},{"name":"Stem Cell Research Center, Department of Hematology Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunim","family":"Shah","sequence":"additional","affiliation":[{"name":"Stem Cell Research Center, Department of Hematology Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Waiz","sequence":"additional","affiliation":[{"name":"Integral Information &amp; Research Center (IIRC\u20105), Clinical Biochemistry &amp; Natural Product Research Lab, Department of Biosciences Integral University  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra P.","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Stem Cell Research Center, Department of Hematology Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5650-748X","authenticated-orcid":false,"given":"Sahir Sultan","family":"Alvi","sequence":"additional","affiliation":[{"name":"Integral Information &amp; Research Center (IIRC\u20105), Clinical Biochemistry &amp; Natural Product Research Lab, Department of Biosciences Integral University  Lucknow Uttar Pradesh India"},{"name":"Department of Medicine and Oncology ISU, School of Medicine University of Texas Rio Grande Valley  McAllen Texas USA"},{"name":"South Texas Center of Excellence for Cancer Research, School of Medicine University of Texas Rio Grande Valley  McAllen Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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