{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:06:33Z","timestamp":1784621193250,"version":"3.55.0"},"reference-count":129,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30873396"],"award-info":[{"award-number":["30873396"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673686"],"award-info":[{"award-number":["81673686"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81073080"],"award-info":[{"award-number":["81073080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873133"],"award-info":[{"award-number":["81873133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81241107"],"award-info":[{"award-number":["81241107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373629"],"award-info":[{"award-number":["81373629"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273640"],"award-info":[{"award-number":["81273640"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81141117"],"award-info":[{"award-number":["81141117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473407"],"award-info":[{"award-number":["81473407"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30973925"],"award-info":[{"award-number":["30973925"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Oxidative stress is recognized to have a central role in the initiation and progression of Parkinson's disease (PD). Within the brain, neurons are particularly sensitive to oxidation due in part to their weak intrinsic antioxidant defense. Theoretically, neurons mostly depend on neighboring astrocytes to provide antioxidant protection by supplying cysteine\u2010containing products for glutathione (GSH) synthesis. Astrocytes and neurons possess several amino acid transport systems for GSH and its precursors. Indeed, GSH is the most abundant intrinsic antioxidant in the central nervous system. The GSH depletion and\/or alterations in its metabolism in the brain contribute to the pathogenesis of PD. Noteworthy, polyphenols possess potent antioxidant activity and can augment the GSH redox system. Numerous in vitro and in vivo studies have indicated that polyphenols exhibit potent neuroprotective effects in PD. Epidemiological studies have found an association between the consumption of dietary polyphenols and a lower PD risk. In this review, we summarize current knowledge on the biosynthesis and metabolism of GSH in the brain, with an emphasis on their contribution and therapeutic potential in PD. In particular, we focus on polyphenols that can increase brain GSH levels against PD. Furthermore, some current challenges and future perspectives for polyphenol\u2010based therapies are also discussed.<\/jats:p>","DOI":"10.1002\/ptr.8342","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T06:50:37Z","timestamp":1726642237000},"page":"5567-5582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Role of Glutathione in Parkinson's Disease Pathophysiology and Therapeutic Potential of Polyphenols"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5610-5897","authenticated-orcid":false,"given":"Chengu","family":"Niu","sequence":"first","affiliation":[{"name":"Internal Medicine Residency Program Rochester General Hospital  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-2039","authenticated-orcid":false,"given":"Miaoxian","family":"Dong","sequence":"additional","affiliation":[{"name":"The Institute of Medicine Qiqihar Medical University  Qiqihar China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5543-3354","authenticated-orcid":false,"given":"Yingcai","family":"Niu","sequence":"additional","affiliation":[{"name":"The Institute of Medicine Qiqihar Medical University  Qiqihar China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122334"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.114"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2024.02.006"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/arch.22027"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2178-5"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03252-x"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.03.024"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10111519"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-023-04008-5"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168689"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2022.2074848"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20200429"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.815771"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/neurolint16030037"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25084158"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgad050"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crphys.2024.100118"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3930"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13050547"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.05.036"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.4c00139"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101263"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.11.008"},{"issue":"2","key":"e_1_2_15_25_1","first-page":"447","article-title":"Glycitein Exerts Neuroprotective Effects in Rotenone\u2010Triggered Oxidative Stress and Apoptotic Cell Death in the Cellular Model of Parkinson's Disease","volume":"69","author":"Dong N.","year":"2022","journal-title":"Acta Biochimica Polonica"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01425-2"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2021.110909"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14462"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.874596"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15020238"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.10.313"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2022.08.006"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12060760"},{"issue":"5","key":"e_1_2_15_34_1","first-page":"4431","article-title":"Tectorigenin Attenuates the MPP+\u2010Induced SH\u2010SY5Y Cell Damage, Indicating a Potential Beneficial Role in Parkinson's Disease by Oxidative Stress Inhibition","volume":"14","author":"Gong P.","year":"2017","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122010366"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.05.004"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16374"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.5603\/FHC.a2020.0011"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.01.025"},{"issue":"11","key":"e_1_2_15_40_1","first-page":"3094","article-title":"On the Role of Iron in Idiopathic Parkinson's Disease","volume":"11","author":"Huenchuguala S.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.15931"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.06.017"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2022.147958"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010324"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.15912"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103213"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2020.108893"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.02.031"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1796-6"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2018.211"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-019-01191-4"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-022-01880-8"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.07.036"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2205874119"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2013.7.4.249"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.5194\/jbji-7-71-2022"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.17541"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115672026297775240405073502"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.1291"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.935054"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-01934-1"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111644"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7769355"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.135848"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.11.022"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12071373"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/23978473221091852"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2022.11.001"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.09.020"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/tpj.16700"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-023-01068-6"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14261"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2022.102191"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-021-02071-5"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-022-03524-1"},{"key":"e_1_2_15_76_1","first-page":"5499","article-title":"Neuroprotective Potential of Ferulic Acid in the Rotenone Model of Parkinson's Disease","volume":"9","author":"Ojha S.","year":"2015","journal-title":"Drug Design, Development and Therapy"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.26333"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-018-1474-8"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.03.186"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-021-02845-6"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03379-x"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.920316"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02942-8"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24994"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.4103\/pm.pm_113_17"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-021-02414-z"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107068"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120354"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121129"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24971"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020296"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-23211"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13020169"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174112"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-024-04116-w"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2022.04.011"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5573"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00717"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2017.04.003"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.1A0820-514R"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2022.105461"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2021.10.003"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2015.11.012"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23164"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2222-21.2022"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.05.012"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.016265"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.06.030"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-024-04147-3"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28242-7"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121683"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2693"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.011"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl8920"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.5582\/ddt.2022.01026"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01595-8"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.09.013"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2738-7"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adl1088"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.11.011"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1212405"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.2147\/EB.S434280"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.846488"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2023_230103N4"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.3c00730"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2024.5660"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14245373"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2007.07.017"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2020.104823"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-24-0016"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.8342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T03:23:14Z","timestamp":1733973794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.8342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,17]]},"references-count":129,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/ptr.8342"],"URL":"https:\/\/doi.org\/10.1002\/ptr.8342","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,17]]},"assertion":[{"value":"2024-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}