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Silybin, derived from <jats:italic>Silybum marianum<\/jats:italic>, has been demonstrated to exhibit a range of beneficial properties, including anti\u2010inflammatory, antioxidative, antifibrotic, antiviral, and cytoprotective effects. These attributes render it a promising candidate for the treatment of liver fibrosis, cirrhosis, liver cancer, viral hepatitis, non\u2010alcoholic fatty liver disease, and other liver conditions. Nevertheless, its low solubility and low bioavailability have emerged as significant limitations in its clinical application. To address these limitations, researchers have developed a number of silybin formulations. This study presents a comprehensive review of the results of research on silybin for the treatment of liver diseases in recent decades, with a particular focus on novel formulations based on the pathogenesis of the disease. These include approaches targeting the liver via the CD44 receptor, folic acid, vitamin A, and others. Furthermore, the study presents the findings of studies that have employed nanotechnology to enhance the low bioavailability and low solubility of silybin. This includes the use of nanoparticles, liposomes, and nanosuspensions. This study reviews the application of silybin preparations in the treatment of global liver diseases. However, further high\u2010quality and more complete experimental studies are still required to gain a more comprehensive understanding of the efficacy and safety of these preparations. Finally, the study considers the issues that arise during the research of silybin formulations.<\/jats:p>","DOI":"10.1002\/ptr.8347","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T09:59:30Z","timestamp":1727085570000},"page":"5713-5740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Silybin: A Review of Its Targeted and Novel Agents for Treating Liver Diseases Based on Pathogenesis"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4597-3733","authenticated-orcid":false,"given":"Jijiao","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu China"},{"name":"School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu 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