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These inflammatory diseases include airway inflammation, asthma, bacterial antigens\u2010induced tonsil epithelial inflammation, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), COVID\u201019, acute lung injury, and lung cancer. This review summarizes the relevant molecular mechanisms of inflammatory diseases in the respiratory tract and the progress of natural bioactive components in inflammatory diseases in the respiratory tract. The natural bioactive components have good therapeutic or intervention effects on inflammatory airway diseases in\u00a0vitro, in\u00a0vivo, and in clinical trials. The information on inflammatory diseases in the respiratory tract and natural bioactive ingredients in anti\u2010inflammatory diseases were collected from famous literature databases such as Web of Science, PubMed, and Google Scholar, with keywords including bioactive components, inflammatory diseases, respiratory tract, and so forth. The bioactive phytochemicals, such as curcumin, ginsenoside, safranal, melatonin, could improve inflammatory diseases through the regulation of PI3K\/Akt, NF\u2010\u03baB, NRF2\/HO\u20101, MAPK, cAMP\u2010PKA, and MEK\/ERK Signaling pathways. Further high\u2010quality studies are still needed to firmly establish the clinical efficacy of bioactive ingredients. This review provides new insight for future research on functional food or drug\u2010lead compound development on natural products improving inflammatory diseases in the respiratory tract.<\/jats:p>","DOI":"10.1002\/ptr.8367","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:49:07Z","timestamp":1754488147000},"page":"4199-4229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Insights Into Effects of Natural Bioactive Components on Inflammatory Diseases in Respiratory Tract"],"prefix":"10.1002","volume":"39","author":[{"given":"Jincan","family":"Luo","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Guangzhou National Laboratory, International 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