{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:16:23Z","timestamp":1791249383948,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The aim of the study was to understand healthcare professionals, pharmacists, and patients perspectives and experiences on clinical practice of herb\u2013drug interactions (HDIs). A systematic review of qualitative studies was conduct. 10 electronic databases were searched from inception through September 2023. Qualitative studies, mixed\u2010method studies, and unstructured or semi\u2010structured cross\u2010sectional surveys focused on healthcare professionals, pharmacists and patients' perspectives, attitudes, clinical practice behaviors, and information needs regarding HDI were included. Thematic synthesis employed Nvivo 12 software. Of 6655 studies identified, 1267 full\u2010text articles were retrieved. Of these, 18 studies conducted in 11 countries\/regions were eligible for inclusion, involving 1273 patients, 302 healthcare professionals, and 230 pharmacists. Five over\u2010arching explanatory themes were identified: perspectives, attitudes, practices, experiences, expectations, and information needs. Complementary and alternative (CAM) physicians, pharmacists, and general practitioners were considered by patients to possess the ability or responsibility to assess potential HDIs. Pharmacists yet encountered difficulties due to conflicting information sources and inadequate training. Healthcare professionals, including pharmacists, usually only assessed HDIs when they were deemed to cause serious adverse effects. Regarding expectations and information needs, patients were particularly concerned about the risk of adverse HDIs, the severity of HDIs, and the appropriate intervals between drug doses. They would like to receive relevant HDI alerts. Results suggest that government, policy makers, healthcare professionals, and the education system should give attention to HDIs and improve health professional\u2014patient communication. Further research should also be conducted on the understanding and practices of CAM practitioners in China.<\/jats:p><jats:p>\n<jats:bold>Trial Registration:<\/jats:bold> CRD42022324777 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/PROSPERO\/#recordDetails\">https:\/\/www.crd.york.ac.uk\/PROSPERO\/#recordDetails<\/jats:ext-link>)<\/jats:p>","DOI":"10.1002\/ptr.8384","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T02:49:59Z","timestamp":1731552599000},"page":"505-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Perspectives, Experiences, and Practices of Healthcare Professionals and Patients Towards Herb\u2013Drug Interaction: A Systematic Review of Qualitative Studies"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-7133","authenticated-orcid":false,"given":"Chen","family":"Shen","sequence":"first","affiliation":[{"name":"Centre for Evidence Based Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Ying","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Di","family":"Lan","sequence":"additional","affiliation":[{"name":"Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Yao","family":"Kong","sequence":"additional","affiliation":[{"name":"Centre for Evidence Based Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine Third Affiliated Hospital  Beijing China"},{"name":"Institute of Acupuncture and Moxibustion in Cancer Care Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Zhu","family":"Su","sequence":"additional","affiliation":[{"name":"Centre for Evidence Based Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Lei","family":"Yue","sequence":"additional","affiliation":[{"name":"Guangxi University of Chinese Medicine  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu\u2010Lin","family":"Wan","sequence":"additional","affiliation":[{"name":"Guang'anmen Hospital, China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Xue","family":"Xiao","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi\u2010Pi","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Evidence Based Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-8158","authenticated-orcid":false,"given":"Xian","family":"Zhou","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute Western Sydney University  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Robinson","sequence":"additional","affiliation":[{"name":"Centre for Evidence Based Chinese Medicine Beijing University of Chinese Medicine  Beijing China"},{"name":"Institute of Health and Social Care London South Bank University  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Centre for Evidence Based Chinese Medicine Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Alhomoud F. 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