{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:59:45Z","timestamp":1790629185648,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102022R1A2C2006229"],"award-info":[{"award-number":["NRF\u20102022R1A2C2006229"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["2E32851"],"award-info":[{"award-number":["2E32851"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Monoamine oxidase B (MAO\u2010B) has emerged as a therapeutic target for Alzheimer's disease (AD) due to its involvement in the synthesis of \u03b3\u2010aminobutyric acid (GABA) in reactive astrocytes, which inhibits neuronal activity. Suffruticosol B (Suf\u2010B), isolated from\n                    <jats:italic>Paeonia lactiflora<\/jats:italic>\n                    , is one of the resveratrol oligomers. Although resveratrol oligomers have demonstrated neuroprotective effects, it remains unexplored whether Suf\u2010B exerts therapeutic effects on AD by targeting MAO\u2010B. In this study, we investigated whether Suf\u2010B alleviates AD pathology by mitigating reactive astrogliosis and inhibiting the overproduction of astrocytic GABA. After confirming the MAO\u2010B inhibitory effect of Suf\u2010B through MAO\u2010B enzyme assay, we administered Suf\u2010B to APP\/PS1 AD model mice. To test the potential therapeutic action of Suf\u2010B in AD, a series of experiments were conducted, including behavioral tests such as the open field test, novel object recognition test, Barnes maze test, passive avoidance test, as well as immunohistochemistry and whole\u2010cell patch\u2010clamp recordings. We found that Suf\u2010B markedly inhibited MAO\u2010B activity without causing cytotoxicity. Immunohistochemistry and electrophysiology experiments demonstrated that Suf\u2010B significantly reduced astrocyte reactivity, as well as an aberrant increase in GABA production and tonic GABA release from astrocytes in AD. Behavior test results indicated that Suf\u2010B treatment restored cognitive function in APP\/PS1 mice. In conclusion, Suf\u2010B effectively reduces excessive GABA production in reactive astrocytes by inhibiting MAO\u2010B, normalizing aberrant inhibition in hippocampal neurons in an AD mouse model. These results suggest that Suf\u2010B has potential as a treatment for AD and may be applicable to other brain diseases associated with reactive astrogliosis.\n                  <\/jats:p>","DOI":"10.1002\/ptr.8395","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T03:24:29Z","timestamp":1732505069000},"page":"593-603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Suffruticosol B from\n                    <i>Paeonia lactiflora<\/i>\n                    Ameliorates Alzheimer's Disease Pathology by Inhibiting\n                    <scp>MAO<\/scp>\n                    \u2010B Activity"],"prefix":"10.1002","volume":"39","author":[{"given":"Jae\u2010Jun","family":"Heo","sequence":"first","affiliation":[{"name":"Brain Science Institute Korea Institute of Science and Technology (KIST)  Seoul Republic of Korea"},{"name":"Department of Biotechnology, College of Life Science and Biotechnology Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Eun","family":"Han","sequence":"additional","affiliation":[{"name":"Brain Science Institute Korea Institute of Science and Technology (KIST)  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Brain Science Institute Korea Institute of Science and Technology (KIST)  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunji","family":"Cheong","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science and Biotechnology Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Whan","family":"Choi","sequence":"additional","affiliation":[{"name":"Natural Biomaterial Team, Biocenter, Gyeonggido Business and Science Accelerator  Suwon Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0900-7386","authenticated-orcid":false,"given":"Soo\u2010Jin","family":"Oh","sequence":"additional","affiliation":[{"name":"Brain Science Institute Korea Institute of Science and Technology (KIST)  Seoul Republic of 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