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BP serves as a candidate amplifier in phototherapy against skin inflammation, such as psoriasis and atopic dermatitis. However, the anti\u2010inflammatory role of BP remains elusive. We utilized IL\u201017A\u2010stimulated keratinocyte line and imiquimod\u2010challenged BALB\/c mice to imitate psoriasis\u2010like inflammation. Inflammatory phenotypes were determined by expressions of inflammatory genes and cytokines, histopathological changes and activities of nuclear factor\u2010\u03baB (NF\u2010\u03baB) pathway. An RNA\u2010seq analysis of rodent skin was performed to explore possible mechanism lying behind. SiRNAs and antagonist (TMS) against cytochrome P450 family 1 subfamily B member 1 (CYP1B1) were subsequently used to determine the role of CYP1B1 in psoriasis pathogenesis in\u00a0vitro and in\u00a0vivo. Overexpression of CYP1B1 with lentivirus further validate therapeutic effect of BP. BP significantly suppressed activation of the NF\u2010\u03baB pathway by inhibiting p65 phosphorylation and improved the inflammatory phenotype both in\u00a0vitro and in\u00a0vivo. We revealed the key role of CYP1B1 in regulating the activation of the NF\u2010\u03baB signaling pathway. Knock\u2010down with siRNAs significantly reduce the expression of inflammatory genes and cytokines. An intraperitoneal injection of TMS partially remediated IMQ\u2010induced inflammation, mainly in terms of skin thickness. Overexpression of\n                    <jats:italic>Cyp1b1<\/jats:italic>\n                    led to increased expression of the CYP1B1 protein and rescued the therapeutic effect of BP in\u00a0vitro. This study revealed that BP suppressed expression of\n                    <jats:italic>Cyp1b1<\/jats:italic>\n                    in keratinocytes and inhibited the activation of NF\u2010\u03baB signaling pathway by blocking the phosphorylation of p65.\n                  <\/jats:p>","DOI":"10.1002\/ptr.8399","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T22:40:13Z","timestamp":1733438413000},"page":"661-675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bergapten Ameliorates Psoriatic Skin Lesions and\n                    <scp>IL<\/scp>\n                    \u2010\n                    <scp>17A<\/scp>\n                    \u2010Induced Activation of the\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Signaling Pathway via the Downregulation of\n                    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