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While efforts in vaccine development and antiviral drug discovery are ongoing, effective therapeutic options remain limited. In this review, we highlight natural compounds and the analogs that demonstrated antiviral activity against DENV in in\u00a0vitro and in\u00a0vivo studies. Specifically, these studies examine alkaloids, phenolic acids, phenols, flavonoids, terpenoids, and glycosides which have shown potential in inhibiting DENV entry, replication, and reducing the cytokine storm. By focusing on these bioactive compounds and the analogs, a comprehensive overview of their promising roles is provided to advance therapeutic strategies for combating DENV infection.<\/jats:p>","DOI":"10.1002\/ptr.8408","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T03:07:07Z","timestamp":1734577627000},"page":"888-921","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Natural Compounds and Their Analogs as Antivirals Against Dengue Virus: A Review"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6325-7079","authenticated-orcid":false,"given":"Amalina Ghaisani","family":"Komarudin","sequence":"first","affiliation":[{"name":"Eijkman Research Center for Molecular Biology National Research and Innovation Agency (BRIN)  Kabupaten Bogor Jawa Barat Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-3148","authenticated-orcid":false,"given":"Azis","family":"Adharis","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Computer Science Universitas Pertamina (UPER)  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0986-2590","authenticated-orcid":false,"given":"R. 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