{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:29:55Z","timestamp":1759962595401},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,5,15]],"date-time":"2002-05-15T00:00:00Z","timestamp":1021420800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Brazilian National Research Council (CNPq)"},{"name":"Research Support Foundation (FUNCAP) Cear\u00e1, Brazil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present work showed the effects of <jats:italic>Myracrodruon urundeuva<\/jats:italic> Fr. All., popularly known as \u2018aroeira\u2019 (AE), in the form of enemas prepared from the stem bark, on several morphologic and morphometric parameters after acetic acid\u2010induced colitis in rats. Enemas from 5\u2010ASA were used as standard while the vehicle, carboxymethylcellulose, was used as a control. The results of the morphological evaluation showed that on day 1 acetic acid produced significantly more necrosis in the groups treated with AE (10% and 20%) or 5\u2010ASA than the controls. However, on day 60, there were more caliciform and absorptive cells in the treated groups compared with the controls. A significantly higher number of eosinophil and mononuclear cells and also collagen deposition in the controls compared with the treated groups were observed on day 60. However, a higher number of polymorphonuclear cells was detected on day 60 only in the AE treated group but not in the 5\u2010ASA group. These data indicate that animals treated with AE or 5\u2010ASA showed complete epithelial tissue regeneration, while in the controls chronic inflammatory exudate persisted and tissue regeneration occurred through fibrosis. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.841","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:48:25Z","timestamp":1030319305000},"page":"267-272","source":"Crossref","is-referenced-by-count":14,"title":["Morphologic and morphometric analyses of acetic acid\u2010induced colitis in rats after treatment with enemas from<i> Myracrodruon urundeuva<\/i> Fr. All. (Aroeira do Sert\u00e3o)"],"prefix":"10.1002","volume":"16","author":[{"given":"Lusmar Veras","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Valdeci","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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