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The primary component of wine, grape seeds, and nuts is polyphenols. Research suggests that polyphenols slow down the rate of neurodegeneration in AD and lessen learning impairment. Furthermore, polyphenols lessen brain impairments related to cognition. Additionally, polyphenols can specifically restructure amyloid\u2010\u03b2 (A\u03b2) structures and soluble oligomers into non\u2010toxic alternative species. They have also been revealed to increase brain\u2010derived neurotrophic factors expression, suggesting that they have a positive impact on the creation of neurotrophins. The benefits of polyphenol supplementation and exercise, which can both provide neuroprotection, have not been well studied in AD patients. This review aimed to investigate the effects of combined exercise polyphenols on inflammation, neuroprotection, several conformational toxic species of A\u03b2, and A\u03b2\u2010induced apoptosis in AD.<\/jats:p>","DOI":"10.1002\/ptr.8422","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T03:23:32Z","timestamp":1735010612000},"page":"1020-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Beneficial Effects of Combined Exercise and Polyphenols in Alzheimer's Disease"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3855-5759","authenticated-orcid":false,"given":"Qinghua","family":"Tan","sequence":"first","affiliation":[{"name":"Graduate School of Education in Physical Education Sangmyung University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"e_1_2_15_2_1","unstructured":"(WHO) W. 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