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Flavonoids, a diverse class of bioactive polyphenolic compounds found in plant\u2010derived foods and beverages, have garnered increasing attention as potential therapeutic agents for improving metabolic health. This review provides a comprehensive analysis of the therapeutic effects of flavonoids in the context of the MetS, with a particular focus on their modulation of the AMP\u2010activated protein kinase (AMPK) pathway. AMPK serves as a central regulator of cellular energy balance, glucose metabolism, and lipid homeostasis, making it a critical target for metabolic intervention. Through a systematic review of the literature up to April 2024, preclinical studies across various flavonoid subclasses, including flavonols, and flavan\u20103\u2010ols, were analysed to elucidate their mechanistic roles in metabolic regulation. Many studies suggests that flavonoids enhance glycolipid metabolism by facilitating glucose transporter 4 (GLUT4) translocation and activating the AMPK pathway, thereby improving glycemic control in diabetes models. In obesity\u2010related studies, flavonoids demonstrated significant inhibitory effects on lipid synthesis, reduced adipogenesis, and attenuated proinflammatory cytokine secretion via AMPK activation. These findings show the broad therapeutic potential of flavonoids in addressing the MetS and its associated disorders. While these preclinical insights highlight flavonoids as promising natural agents for metabolic health improvement, it is important to note that their excessive concentrations may disrupt these pathways, potentially leading to metabolic imbalance and cytotoxicity. Further studies and clinical trials are essential to determine optimal dosing regimens, formulations, and the long\u2010term safety and efficacy of flavonoids. This review highlights the importance of flavonoids for natural interventions targeting MetS and its comorbidities, offering a foundation for future translational research.<\/jats:p>","DOI":"10.1002\/ptr.8428","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T01:34:28Z","timestamp":1736472868000},"page":"1403-1421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Exploring the Therapeutic Role of Flavonoids Through\n                    <scp>AMPK<\/scp>\n                    Activation in Metabolic Syndrome: A Narrative Review"],"prefix":"10.1002","volume":"39","author":[{"given":"Lunasmrita","family":"Saikia","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Science Assam Down Town University  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayaran 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