{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:37:27Z","timestamp":1792204647165,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["APVV\u201015\u20100296"],"award-info":[{"award-number":["APVV\u201015\u20100296"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006109","name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","doi-asserted-by":"publisher","award":["VEGA 1\/0680\/22"],"award-info":[{"award-number":["VEGA 1\/0680\/22"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This narrative review describes the provenance and chemical composition of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Vitex agnus\u2010castus<\/jats:italic>\n                    <\/jats:styled-content>\n                    , as well as the currently available knowledge concerning its action. To search the related articles, Cochrane Library, PubMed, Web of Science, SCOPUS databases between the years 1995 and 2024, and the keywords \u201cVitex,\u201d \u201creview,\u201d \u201cfertility,\u201d \u201covarian\u201d and \u201cmechanisms\u201d were used in various combinations. The data listed in this review demonstrate that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Vitex agnus\u2010castus<\/jats:italic>\n                    <\/jats:styled-content>\n                    and its constituents (isoflavones and essential oils) affect a number of physiological actions via multiple extra\u2010 and intracellular mechanisms of action. This makes it an efficient drug in both traditional and modern medicine for the treatment of a number of illnesses. The main described target of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Vitex agnus\u2010castus<\/jats:italic>\n                    <\/jats:styled-content>\n                    is female reproduction. It can up\u2010regulate ovarian cycle and fecundity via a wide spectrum of mediators from hypothalamic, pituitary and ovarian hormones up to intracellular regulators of proliferation, apoptosis, oxidation and dopamine receptors. These effects determine its potential action as protector and medicine against a number of female reproductive disorders and reproduction\u2010related health problems including menstrual disorders, premenstrual syndrome, cyclic mastalgia, corpus luteum insufficiency, abnormal production of progesterone and prolactin, low fertility and infertility, hyperandrogenism and polycystic ovarian syndrome. Nevertheless, further high\u2010quality studies are needed to firmly establish the biological and clinical efficacy of this plant.\n                  <\/jats:p>","DOI":"10.1002\/ptr.8438","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T03:26:25Z","timestamp":1737689185000},"page":"1484-1493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects, Mechanisms of Action and Application of\n                    <scp>\n                      <i>Vitex agnus\u2010castus<\/i>\n                    <\/scp>\n                    for Improvement of Health and Female Reproduction"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-3512","authenticated-orcid":false,"given":"Alexander V.","family":"Sirotkin","sequence":"first","affiliation":[{"name":"Constantine the Philosopher University in Nitra  Nitra Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2016.05.006"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.26574\/maedica.2022.17.4.799"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2019.31692.7625"},{"issue":"3","key":"e_1_2_15_5_1","first-page":"185","article-title":"Vitex agnus castus Extract Improves Learning and Memory and Increases the Transcription of Estrogen Receptor \u03b1 in Hippocampus of Ovariectomized Rats","volume":"6","author":"Allahtavakoli M.","year":"2015","journal-title":"Basic and Clinical Neuroscience"},{"issue":"5","key":"e_1_2_15_6_1","first-page":"36","article-title":"Hormonal Regulation in Pcos Using Acupuncture and Herbal Supplements: A Case Report and Review of the Literature","volume":"18","author":"Alois M.","year":"2019","journal-title":"Integrative Medicine: A Clinician's Journal"},{"issue":"1","key":"e_1_2_15_7_1","first-page":"67","article-title":"Vitex agnus\u2010castus\n                  . Monograph","volume":"14","author":"Anonimous","year":"2009","journal-title":"Alternative Medicine Review"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.26574\/maedica.2019.14.3.274"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106882\u201014\u2010511"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.05.004"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138731"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1303696"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2018.03.001"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.12.003"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2639"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018\u2010200528040\u201000004"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.010843"},{"key":"e_1_2_15_18_1","unstructured":"Drugs and Lactation Database (LactMed).2024.[Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006. Chasteberry."},{"issue":"1","key":"e_1_2_15_19_1","first-page":"1","article-title":"Effects of \u2018Vitex agnus castus\u2019 Extract and Magnesium Supplementation, Alone and in Combination, on Osteogenic and Angiogenic Factors and Fracture Healing in Women With Long Bone Fracture","volume":"19","author":"Eftekhari M. H.","year":"2014","journal-title":"Journal of Research in Medical Sciences"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001\u20103765201720170428"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2007.06.003"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786410701592612"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12750"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5591"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010024\u201001378\u20104"},{"issue":"3","key":"e_1_2_15_27_1","first-page":"218","article-title":"Antinociceptive Effects, Acute Toxicity and Chemical Composition of \n                     Vitex agnus\u2010castus\n                   Essential Oil","volume":"5","author":"Khalilzadeh E.","year":"2015","journal-title":"Avicenna Journal of Phytomedicine"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2454"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0031\u20109422(03)00285\u20101"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.09.012"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.5935\/1518\u20100557.20220024"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40199\u2010019\u201000312\u20100"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1515\/jcim\u20102018\u20100053"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/212378"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2007.2300.2307"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.26.10"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.02.016"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2019.7770"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1324429"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2016.1256002"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.19082\/3685"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973\u20107847.120522"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001\u20103765202020180569"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2711"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010022\u201002625\u20107"},{"key":"e_1_2_15_47_1","first-page":"194","volume-title":"Regulators of Ovarian Functions","author":"Sirotkin A. V.","year":"2014"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010020\u201010739\u20107"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010020\u201011082\u20107"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.14476"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10091859"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2016.07.007"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101327831"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.02.028"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14943"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1078\/094471103322004866"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116273"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.4103\/jehp.jehp_870_22"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.8438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:01:37Z","timestamp":1741694497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.8438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/ptr.8438"],"URL":"https:\/\/doi.org\/10.1002\/ptr.8438","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"assertion":[{"value":"2024-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}