{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:59:23Z","timestamp":1790823563666,"version":"4.1.0"},"reference-count":133,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202208515025"],"award-info":[{"award-number":["202208515025"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Metabolic diseases (MD), a series of chronic disorders, severely decrease the quality of life for patients but also cause a heavy economic burden. The ancient Chinese herb\n                    <jats:italic>Pueraria<\/jats:italic>\n                    Radix (PR) plays an important role in curing MD. Up to now, the bioactive compounds found in PR demonstrate effective actions in treating various metabolic disorders. This paper systematically summarizes the recent research advances on the pharmacological activities of PR and its constituents, explains the underlying mechanisms of preventing and treating MD. Besides, phytochemicals, drug delivery systems, clinical application, and safety of PR have been researched, hoping to provide valuable information for the future application, development, and improvement of PR as well as MD treatment. The information about PR was collected from various sources including classic books about Chinese herbal medicine and scientific databases including Web of Science, PubMed, ScienceDirect, Springer, ACS, SCOPUS, CNKI, Google Scholar, X\u2010MOL, and WANFANG using keywords given and terms like pharmacological and phytochemical details of this plant. The chemical constituents isolated and identified from PR, such as isoflavones including puerarin, formononetin, daidzin, daidzein, genistein, and so forth, polysaccharides, alkaloids, starch, and other components have been proved to have the effect of anti\u2010diabetic, anti\u2010obesity, anti\u2010atherosclerotic, anti\u2010osteoporotic, anti\u2010hypertensive, anti\u2010hyperlipidemia, and anti\u2010nonalcoholic fatty liver disease (NAFLD) through PI3K\/Akt, Nrf2\/HO\u20101, LOX\u20101\/ROS\/Akt\/eNOS, ERK1\/2\u2010Nrf2, GLP\u20101R, Caspase, MAPK, NF\u2010\u03baB, and other anti\u2010inflammatory and anti\u2010oxidant signaling pathways. Also, the active contents of PR have been designed as drug delivery systems to improve the therapeutic effects of MD. It provides a preclinical basis for the efficacy of PR as an effective therapeutic agent for the prevention and treatment of MD. Even so, further studies are still needed to enhance bioavailability and expand clinical application.\n                  <\/jats:p>","DOI":"10.1002\/ptr.8464","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T07:30:54Z","timestamp":1742283054000},"page":"5521-5550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Pueraria<\/i>\n                    Radix and Its Major Constituents Against Metabolic Diseases: Pharmacological Mechanisms and Potential Applications"],"prefix":"10.1002","volume":"39","author":[{"given":"Yicheng","family":"Lei","sequence":"first","affiliation":[{"name":"Pharmacy College of Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Southwestern Chinese Medicine Resources  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pharmacy College of Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Southwestern Chinese Medicine Resources  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Pharmacy College of Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Southwestern Chinese Medicine Resources  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Pang","sequence":"additional","affiliation":[{"name":"Australian Institute for Bioengineering and Nanotechnology, The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biomedical Science, The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1096-1572","authenticated-orcid":false,"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Pharmacy College of Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Southwestern Chinese Medicine Resources  Chengdu China"},{"name":"Australian Institute for Bioengineering and Nanotechnology, The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168555"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169465"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2013.096"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp\u20102013\u20100322"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.80"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.153075"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6659240"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.16498\/j.cnki.hnnykx.2010.13.003"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24050955"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.10.033"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387\u2010017\u20100009\u20106"},{"issue":"1","key":"e_1_2_12_13_1","first-page":"53","article-title":"Research Progress on Chemical Constituents and Pharmacological Effects of Gegen","volume":"12","author":"Chen Y.","year":"2021","journal-title":"Pharmacy and Clinics of Chinese Materia Medica"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104210"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020276"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25092042"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17043"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4350"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179602"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.10.018"},{"issue":"4","key":"e_1_2_12_21_1","first-page":"64","article-title":"Nutritional Health Function of Pueraria Lobata and Its Research Progress on Application in Starch\u2010Based Food","volume":"48","author":"Deng M.","year":"2023","journal-title":"Grain Processing"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.16782\/j.cnki.32\u20101235\/ts.2023.04.001"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.04.021"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.103922"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.19590\/j.cnki.1008\u20101038.2022.10.007"},{"key":"e_1_2_12_26_1","unstructured":"Fan M. Y.2022.\u201cStudy on Chemical Constituents of Theroots ofPueraria Lobata(Willd.) Ohwiand Screening of Chinese Herbalextracts With PTP1B Inhibitory.\u201dJiangxi University of Chinese Medicine.https:\/\/doi.org\/10.27180\/d.cnki.gjxzc.2022.000282."},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.997018"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010021\u201003345\u20108"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217253"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.8317"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.10.005"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403x15666190730095153"},{"issue":"4","key":"e_1_2_12_33_1","first-page":"481","article-title":"A Clinical Observation of Gegenqinlian Decoction Combined With Saxagliptin in the Treatment of Type 2 Diabetes Mellitus","volume":"35","author":"Gong J.","year":"2019","journal-title":"Journal of Practical Traditional Chinese Medicine"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.13193\/j.issn.1673\u20107717.2022.03.003"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2017.08.010"},{"issue":"10","key":"e_1_2_12_36_1","first-page":"82","article-title":"Clinical Study of Puerarin Combined With \u03b1\u2010Lipoic Acid in the Treatment of Diabetes Mellitus With Carotid Atherosclerosis","volume":"17","author":"He G. X.","year":"2020","journal-title":"China Medical Herald"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.16736\/j.cnki.cn41\u20101434\/ts.2022.24.019"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.19694\/j.cnki.issn2095\u20102457.2019.26.041"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150610446"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.09.001"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9400"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1691\/ph.2016.5703"},{"issue":"3","key":"e_1_2_12_43_1","first-page":"325","article-title":"Therapeutic Potential for Amyotrophic Lateral Sclerosis Through Regulating Mitochondrial Energy Metabolism via Activating AMPK\/SIRT1\/PGC\u20101\u03b1 Signaling Pathway","volume":"38","author":"Huang C. H.","year":"2022","journal-title":"Chinese Pharmacological Bulletin"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9010033"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.01.028"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.5487\/tr.2015.31.2.191"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7924400"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.119"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110923"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113290"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1017885"},{"key":"e_1_2_12_52_1","first-page":"104","article-title":"The Research on the Extraction of Isoflavones From Puerarin in Lobata and Edible Puerarin in Lobata Production","volume":"06","author":"Li H. T.","year":"2006","journal-title":"Food Research & Development"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2022.2099430"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.120197"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1530\/jme\u201013\u20100302"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010019\u201004925\u20101"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2019.1660732"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2016.06.007"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.09.007"},{"key":"e_1_2_12_60_1","unstructured":"Liu H.2009.\u201cStudy on the Chemical Constituents of the Root ofPueraria Lobata.\u201dSgenyang Pharmaceutical University."},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2017.11.018"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2016.1190742"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.8746"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111325"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.16352\/j.issn.1001\u20106325.2016.11.022"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2021.1898648"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154161"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12245"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201031109\u20106"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154892"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.04140510"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.118.022063"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.03.024"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00739"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x17500938"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401062"},{"key":"e_1_2_12_78_1","unstructured":"Qian K.2020.\u201cStudy on Isolation Structure Characterization and Hypoglycemic Activity ofPueraria LobataPolysaccharides.\u201dJiangxi University of Traditional Chinese Medicine.https:\/\/doi.org\/10.27180\/d.cnki.gjxzc.2020.000171."},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo01234c"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216657445"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.10.029"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2023.10.009"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2018"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.10.007"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x19500022"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.13862\/j.cnki.cn43\u20101446\/r.2017.12.035"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.5246\/jcps.2014.06.048"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4448048"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2019.01181"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.071"},{"key":"e_1_2_12_91_1","unstructured":"Su T. D.2017.\u201cA Comparative Study of Major Kudzu Varieties From Thailand and China.\u201dBeijing University of Chinese Medicine."},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114005"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.02.046"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x17500641"},{"issue":"2","key":"e_1_2_12_95_1","first-page":"183","article-title":"To Explore the Application of Pueraria category's Formulation in Diabetes Mellitus and Its Complications","volume":"40","author":"Tan Y. M.","year":"2021","journal-title":"Journal of Tianjin University of Traditional Chinese Medicine"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.03.003"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2012.07.010"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2012.09.024"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.10.008"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010018\u20102206\u20109"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153222"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.11.005"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218490"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110734"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.8731"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120696"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.04.012"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14193926"},{"issue":"10","key":"e_1_2_12_109_1","first-page":"59","article-title":"Study on the Prevention and Treatment of Osteoporosis by Edible Soybean Extract Daidzin","volume":"5","author":"Wei C. M.","year":"2018","journal-title":"Diet Health"},{"issue":"3","key":"e_1_2_12_110_1","first-page":"136","article-title":"Puerariae Radix Processing Status and Its Comprehensive Utilization in Beverage Development","volume":"21","author":"Wei J. N.","year":"2021","journal-title":"Storage & Process"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201001149\u2010x"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.16548\/j.2095\u20103720.2018.07.001"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00345"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.16190\/j.cnki.45\u20101211\/r.2023.04.005"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2015.1069255"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo02761h"},{"key":"e_1_2_12_117_1","unstructured":"Xu X. Y.2020.\u201cStudy on the Analysis of Saccharides and the Extraction Purification and Structure Identification of Peuraria Polysaccharides.\u201dShanghai Jiao Tong University.https:\/\/doi.org\/10.27307\/d.cnki.gsjtu.2020.003042."},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2011.07.010"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.01.016"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2015\u20101213"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2022.111401"},{"key":"e_1_2_12_122_1","unstructured":"Yang Y. F.2023.\u201cThe Effect and Mechanism ofPueraria LobataStarch on Alleviating Ulcerative Colitis and Non\u2010Alcoholic Fatty Liver Disease in Mice.\u201dSouthwest Medical University.https:\/\/doi.org\/10.27215\/d.cnki.glzyu.2023.000375."},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1875\u20105364(16)30026\u20107"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.19.0004"},{"issue":"1","key":"e_1_2_12_125_1","first-page":"353","article-title":"Progress in Research on Composition, Structure, Functions and Mechanism of Action of Radix Puerariae Isoflavones","volume":"44","author":"Zeng W. S.","year":"2023","journal-title":"Food Science"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.13457\/j.cnki.jncm.2022.12.020"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.09.054"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.13313\/j.issn.1673\u20104890.20230711003"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122925"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.16040\/j.cnki.cn15\u20101101.2020.06.001"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.956688"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo02356f"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2022.105284"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5083"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.8464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T07:31:14Z","timestamp":1765783874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.8464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":133,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ptr.8464"],"URL":"https:\/\/doi.org\/10.1002\/ptr.8464","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]},"assertion":[{"value":"2024-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}