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T helper (Th) cells paradigm disequilibrium is a critical for pathogenesis. Maslinic acid (MA), a naturally occurring pentacyclic triterpene isolated from olive pomace and <jats:italic>Fructus crataegi<\/jats:italic>, has a variety of applications in both medicine and food. This study investigated the molecular mechanism of the anti\u2010inflammatory potential of MA in a colitis model and activated Th cells. A dextran sulfate sodium\u2010induced experimental colitis model was established. Clinical symptoms were evaluated, and biological samples were collected to examine intestinal mucosal function, inflammation levels, and Th cell\u2010mediated immune responses. The mechanism of the activation\u2010induced cell death (AICD) effect regulated by MA was investigated in the anti\u2010CD3\u03b5\/CD28\u2010stimulated Th cell activation model using molecular biotechnology and transcriptome analysis. Key results:MA treatment protected intestinal mucosa, which manifested as reduced inflammatory cytokines, Th cell infiltration, and subset differentiation. Additionally, it was found to suppress Th cell proliferation and differentiation of subsets, regulate cell cycle distribution, and promote AICD by regulating the mitochondria\u2010mediated intrinsic pathway in\u00a0vitro. JAK\u2013STAT and Fc\u03b5RI pathways were probable essential pathways, and MAF might be a crucial potential targeting molecule in activated Th cells with MA treatment. This finding demonstrated that MA induced remission of the colitis\u2010related inflammation, which may depend on the resolution of acute inflammation by reducing Th cell\u2010mediated inflammation via AICD induction, emphasizing its promising potential in the treatment of UC.<\/jats:p>","DOI":"10.1002\/ptr.8479","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T05:22:12Z","timestamp":1744867332000},"page":"2689-2706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Maslinic Acid Ameliorates <scp>DSS<\/scp>\u2010Induced Experimental Colitis by Suppressing Th Cell\u2010Mediated Inflammation via <scp>AICD<\/scp> Induction"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3496-1673","authenticated-orcid":false,"given":"Dan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Affiliated Guangdong Second Provincial 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