{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:53:23Z","timestamp":1790855603830,"version":"4.1.0"},"reference-count":147,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:00:00Z","timestamp":1743292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    There has been an upsurge in the incidences of skin disorders and their mortalities owing to various environmental, hormonal, and epigenetic risk factors. Melanoma, atopic dermatitis, psoriasis, and photoaging and associated consequences are largely observed in the population globally. The social stigma, economic burden, and adverse effects from chronic medication endured by the patients emphasize the necessity of more effective natural therapeutics. Carotenoids are economically valuable tetraterpenoid pigments synthesized by plants and microorganisms, which play a paramount role in their overall growth and development. Extensive in\u00a0vitro and in\u00a0vivo investigations evidenced that phytopigments like carotenoids target multiple intracellular signaling pathways involving the mitogen\u2010activated protein kinases, Janus kinase\/signal transducers, and activators of transcription, apoptotic, and autophagy proteins to ameliorate melanoma. Besides, carotenoids curbed the activation and the release of immunoregulatory molecules such as cytokines and chemokines to abrogate skin immune disorders, photoaging, and associated consequences. Here, we provide a holistic discussion on the pathophysiology of prominent skin disorders and the ameliorating effects of carotenoids as evidenced in the in\u00a0vitro\n                    <jats:italic>,<\/jats:italic>\n                    in\u00a0vivo\n                    <jats:italic>,<\/jats:italic>\n                    and clinical interventions. We also advocate the requisite of formulating carotenoid medications after extensive clinical interventions and validation for mitigating various skin dysfunctions.\n                  <\/jats:p>","DOI":"10.1002\/ptr.8480","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T22:02:23Z","timestamp":1743458543000},"page":"2513-2532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Substantial Effects of Carotenoids on Skin Health: A Mechanistic Perspective"],"prefix":"10.1002","volume":"39","author":[{"given":"Ressin","family":"Varghese","sequence":"first","affiliation":[{"name":"School of Bio Sciences and Technology Vellore Institute of Technology  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Emerson","sequence":"additional","affiliation":[{"name":"School of Bio Sciences and Technology Vellore Institute of Technology  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Vannier","sequence":"additional","affiliation":[{"name":"CoMeT Laboratory (UR 24344), Cell Communications and Microenvironment of Tumours Universit\u00e9 of Poitiers  Poitiers Cedex 9 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"George Priya Doss","sequence":"additional","affiliation":[{"name":"School of Bio Sciences and Technology Vellore Institute of Technology  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7889-7765","authenticated-orcid":false,"given":"Rossyda","family":"Priyadharshini","sequence":"additional","affiliation":[{"name":"Universitas Pembangunan Nasional Veteran Jatim  Surabaya, East Java Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2637-1681","authenticated-orcid":false,"given":"Thomas","family":"Efferth","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7509-8602","authenticated-orcid":false,"given":"Siva","family":"Ramamoorthy","sequence":"additional","affiliation":[{"name":"School of Bio Sciences and Technology Vellore Institute of Technology  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.19070\/2332\u20102977\u20102000054"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.11.019"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2013.12.025"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.0160"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010pathol\u2010012513\u2010104658"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12541"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11071"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100781.2000.160601.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1955175"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2023.08.209"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102121\u201014\u201032"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.040"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26020333"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2017.10.006"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.016"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.01.005"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00003.2012"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.340"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000305548"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/19768354.2018.1523806"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12617"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2010.01191.x"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081451"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.11.025"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2009.02.003"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/physiologia4010005"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010023\u201001178\u20100"},{"issue":"2","key":"e_1_2_13_29_1","first-page":"283","article-title":"Anticancer Effect of Dunaliella salina Under Stress and Normal Conditions Against Skin Carcinoma Cell Line A431 In\u00a0Vitro","volume":"11","author":"Emtyazjoo M.","year":"2012","journal-title":"Iranian Journal of Fisheries Sciences"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22389"},{"key":"e_1_2_13_31_1","unstructured":"Fact. MR.2023.764Anti\u2010aging and Anti\u2010wrinkle Products Market Analysis by Serums Creams and Gels for Body Care Treatments and Facial Care Treatments from 2023 to 2033.\u201dhttps:\/\/www.factmr.com\/report\/4337\/anti\u2010aging\u2010and\u2010anti\u2010wrinkle\u2010products\u2010market#:~:text=The%20global%20anti%2Daging%20and 6.3%25%20from%202023%20to%202033."},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03664"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.943483"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(98)12168\u20102"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101102"},{"key":"e_1_2_13_36_1","doi-asserted-by":"crossref","unstructured":"Harrison E. H.2022. \u201cCarotenoids \u03b2\u2010Apocarotenoids and Retinoids: The Long and the Short of It. Nutrients 2022; 14(7): 1411.\u201d14.https:\/\/doi.org\/10.3390\/nu14071411.","DOI":"10.3390\/nu14071411"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520618666171213143455"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.13350"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.024"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/md20070414"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12469"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671\u2010020\u201000288\u20100"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/life10090193"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13034"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.12.746"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10070817"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15030263"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5408.2002.00004.x"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjp.2018.05.009"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14003"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184347"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112412"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2fo02338e"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.13045\/jar.2022.00255"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13030"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2019.40.4202"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2013.3.2.79"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2012.10.002"},{"issue":"4","key":"e_1_2_13_59_1","first-page":"278","article-title":"Diagnosis and Management of Psoriasis","volume":"63","author":"Kim W. B.","year":"2017","journal-title":"Canadian family physician Medecin de famille canadien"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103086"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2359"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.565285"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2fo01111e"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8020018"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.476"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081273"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4617"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants10102129"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.658757"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701213"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101390"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2016.10.001"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12860\u2010023\u201000466\u20105"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153676"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2016.08.004"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.08.019"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a015354"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010016\u20100170\u20101"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.23937\/2643\u20104466\/1710018"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.53730\/ijhs.v6nS3.5241"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.54133\/ajms.v4i.118"},{"key":"e_1_2_13_82_1","unstructured":"National Psoriasis Foundation.2022.\u201cPsoriasis Statistics.\u201dhttps:\/\/www.psoriasis.org\/psoriasis\u2010statistics\/."},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12492"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1893"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1159\/000370220"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.07.036"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.02.013"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43450\u2010020\u201000036\u20102"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2022.10.005"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1159\/000101807"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12726"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13437"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112344"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008672"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010017\u20100673\u20107"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12495"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12145"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.08.016"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.01.014"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.29"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2017.11.4"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/md16100378"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9121371"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00287"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010022\u201001598\u20108"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061483"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31559\u20109"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100781.2003.00054.x"},{"key":"e_1_2_13_110_1","first-page":"1371","article-title":"Photocarcinogenesis and Skin cancer Prevention Strategies","volume":"36","author":"Seebode C.","year":"2016","journal-title":"Anticancer Research"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.21776\/ub.jkb.2022.032.01.12"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4fo00035h"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.4236\/oalib.1105871"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12071521"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20107158.2010.01139.x"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.06.009"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.11.001"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084130"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.02.009"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111625"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122660"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.ess19092"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101747.1998.00347.x"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12155"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad339"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.08.007"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054948"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.110040"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2023.07.009"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153859"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154850"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.034033"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1193"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6865"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103132"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2024.106165"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.02.042"},{"key":"e_1_2_13_138_1","unstructured":"WHO.2023.\u201cWHO's first global meeting on skin NTDs calls for greater efforts to address their burden.\u201dhttps:\/\/www.who.int\/news\/item\/31\u201003\u20102023\u2010who\u2010first\u2010global\u2010meeting\u2010on\u2010skin\u2010ntds\u2010calls\u2010for\u2010greater\u2010efforts\u2010to\u2010address\u2010their\u2010burden."},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1146\/10.1038\/ng.910"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12632"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/392305"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.15913"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248\u2010018\u20100197\u20106"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12768"},{"issue":"4","key":"e_1_2_13_145_1","first-page":"1163","article-title":"Picrocrocin Exhibits Growth Inhibitory Effects Against SKMEL\u2010 2 Human Malignant Melanoma Cells by Targeting JAK\/ STAT5 Signaling Pathway, Cell Cycle Arrest and Mitochondrial Mediated Apoptosis","volume":"23","author":"Yu L.","year":"2018","journal-title":"Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2164557"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2013.030"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201004523\u20103"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.8480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:37:17Z","timestamp":1754483837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.8480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,30]]},"references-count":147,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/ptr.8480"],"URL":"https:\/\/doi.org\/10.1002\/ptr.8480","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,30]]},"assertion":[{"value":"2024-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}