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This study investigates whether dietary fiber supplementation can prevent cardiovascular damage and high blood pressure in a genetic model of neurogenic hypertension. Six\u2010week\u2010old male spontaneously hypertensive rats (SHR) and their respective normotensive control, Wistar Kyoto rats (WKY), were divided into four groups: Untreated WKY, untreated SHR, SHR treated with resistant starch (SHR\u2009+\u2009RS), and SHR treated with inulin\u2010type fructans (SHR\u2009+\u2009ITF) for 12\u2009weeks. Additionally, a faecal microbiota transplantation (FMT) experiment was conducted, transferring faecal content from treated SHR donors to recipient SHRs. A diet rich in RS fiber reduced vascular oxidative stress, inflammation, and high blood pressure. These protective effects were associated with a reshaped gut microbiota, leading to increased short\u2010chain fatty acid production, reduced endotoxemia, decreased sympathetic activity, and a restored balance between Th17 and Treg lymphocytes in mesenteric lymph nodes and aorta. Elevated plasma levels of acetate and butyrate in the SHR\u2009+\u2009RS group correlated with increased expression of aortic GPR41, GRP43 and PPAR\u03b4. Conversely, ITF treatment failed to prevent hypertension or endothelial dysfunction in SHR. FMT from the SHR\u2009+\u2009RS group to recipient SHR partially replicated these beneficial effects. This study highlights the antihypertensive benefits of dietary insoluble RS fiber, which are attributed to enhanced short\u2010chain fatty acids production in the gut. This leads to improved gut permeability, reduced sympathetic tone, and diminished vascular T\u2010cell accumulation. Therefore, dietary interventions with RS fiber may offer promising therapeutic strategies for preventing hypertension.<\/jats:p>","DOI":"10.1002\/ptr.8484","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T22:44:22Z","timestamp":1742769862000},"page":"1858-1875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Protective Effect of Dietary Fiber on Blood Pressure and Vascular Dysfunction Through Regulation of Sympathetic Tone and Immune Response in Genetic Hypertension"],"prefix":"10.1002","volume":"39","author":[{"given":"Cristina","family":"Gonz\u00e1lez\u2010Correa","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy and Center for Biomedical Research (CIBM) University of Granada  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Granada, Ibs.GRANADA  Granada 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