{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:31:48Z","timestamp":1793269908802,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014996","name":"Health Commission of Zhejiang Province","doi-asserted-by":"publisher","award":["2025KY971"],"award-info":[{"award-number":["2025KY971"]}],"id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Irreversible renal damage in lupus nephritis (LN) results from critical podocyte injury. Disruption in the actin cytoskeleton initiates mitochondrial fission to exacerbate podocyte injury. While ginsenoside compound K (CK) alleviates podocyte injury in lupus\u2010prone mice, its mechanism in regulating mitochondrial dynamics underlying remains elusive. Based on the open\u2010source single\u2010cell RNA sequencing dataset, this study clarified CK's role in alleviating podocyte injury in MRL\/\n                    <jats:italic>lpr<\/jats:italic>\n                    mice by regulating cytoskeleton\u2010mediated mitochondrial fission and elucidated the molecular mechanisms underlying the BA receptor\u2013YAP axis. MRL\/\n                    <jats:italic>lpr<\/jats:italic>\n                    mice were administered CK (20 or 40\u2009mg\/kg) for 10\u2009weeks. Renal function and pathological changes were evaluated, along with renal metabolite profiles and metabolomics analysis. We analyzed publicly available single\u2010cell RNA sequencing data to specifically profile gene mapping and enrichment analysis during immune\u2010mediated renal injury. Furthermore, podocyte\u2010based in\u00a0vitro assays were conducted to investigate the impact of the BA receptors\u2013YAP axis on mitochondrial dynamics. CK effectively cleared anti\u2010dsDNA antibodies, attenuated systemic inflammation, and improved renal function through resolving immune complex deposition. Mechanistically, CK restored actin cytoskeleton integrity via Rho GTPase regulation and reshaped BA metabolism to activate TGR5\/FXR receptors in podocytes. This dual action suppressed DRP1\n                    <jats:italic>s616<\/jats:italic>\n                    phosphorylation, inhibiting excessive mitochondrial fission, regulating while enhancing TFAM\u2010mediated mtDNA replication for mitochondrial homeostasis. Concurrently, CK attenuated podocyte apoptosis through Hippo signaling inhibition and YAP activation. In conclusion, CK ameliorates podocyte injury by preventing excessive mitochondrial fission through the BA receptors\u2013YAP axis, thus providing a potential therapy for LN.\n                  <\/jats:p>","DOI":"10.1002\/ptr.8492","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:29:14Z","timestamp":1750220954000},"page":"4722-4736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ginsenoside Compound K Mitigates Mitochondrial Fission Through Bile Acid Receptors\/\n                    <scp>YAP<\/scp>\n                    Signaling to Counteract Podocyte Injury in Lupus Nephritis"],"prefix":"10.1002","volume":"40","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[{"name":"First School of Clinical Medicine Zhejiang Chinese Medical University  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Song","sequence":"additional","affiliation":[{"name":"First School of Clinical Medicine Zhejiang Chinese Medical University  Hangzhou People's Republic of China"},{"name":"General Practice First Affiliated Hospital of Zhejiang Chinese Medicine University  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumei","family":"Xu","sequence":"additional","affiliation":[{"name":"First School of Clinical Medicine Zhejiang Chinese Medical University  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"First School of Clinical Medicine Zhejiang Chinese Medical University  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangda","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology First Affiliated Hospital of Zhejiang Chinese Medical University  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-6590","authenticated-orcid":false,"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Basic Medical Science Institute of Basic Research in Clinical Medicine, Zhejiang Chinese Medical University  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3600-8915","authenticated-orcid":false,"given":"Fengyuan","family":"Tian","sequence":"additional","affiliation":[{"name":"First School of Clinical Medicine Zhejiang Chinese Medical University  Hangzhou People's Republic of China"},{"name":"General Practice First Affiliated Hospital of Zhejiang Chinese Medicine University  Hangzhou People's Republic of China"},{"name":"College of Basic Medical Science Institute of Basic Research in Clinical Medicine, Zhejiang Chinese Medical University  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015101096"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010019\u20102110\u20103"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201005214\u20109"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151876"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010021\u201000773\u20104"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00965"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13296"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020020220"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.08.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad169"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016111220"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011040370"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010physiol\u2010020911\u2010153238"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aap8030"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101785\u2010z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050502"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2022.10.004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2310"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.7.3915"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2017.04.011"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19830"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01951"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010312485"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090517"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.08.035"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101851"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12886"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976\u20100105.177703"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.01.016"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11124"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102248"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021020182"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf8165"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011121206"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.01.009"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.07.027"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101865\u20100"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2023.11.006"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0065\u20102776(08)60342\u20109"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109405"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201006\u20102913"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201002068\u20100"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108909"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.01.009"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017020222"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14156"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00512.2017"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900284"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010019\u20100313\u20106"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.759421"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010018\u20100613\u20105"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.8492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.8492","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.8492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T09:33:54Z","timestamp":1793266434000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.8492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ptr.8492"],"URL":"https:\/\/doi.org\/10.1002\/ptr.8492","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,18]]},"assertion":[{"value":"2024-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}