{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:18:12Z","timestamp":1782940692672,"version":"3.54.5"},"reference-count":72,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20297"],"award-info":[{"award-number":["U21A20297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Depression often develops in young individuals and is linked to complications like cognitive impairment. Conventional antidepressants show limited efficacy in restoring cognitive function and may cause adverse effects. Green tea, a safe and health\u2010promoting beverage, offers various health benefits. This study investigated the effects of long\u2010term green tea consumption on stress\u2010induced depression\u2010like behavior and mild cognitive impairment in animal models. We established a rodent model of mild depression and studied the effects of green tea on depression\u2010like behavior and cognitive impairment through comprehensive evaluation, including behavioral assessments, neurotransmitter quantification, gene and protein expression analysis, blood metabolite profiling, and gut microbiota characterization. Results demonstrated significant improvements in mood, long\u2010term memory, and sterol and glycerophospholipid metabolism. Green tea repaired the intestinal barrier and upregulated genes vital for tight junctions and mucin production. It also enhanced gut microbiota composition, reducing the Firmicutes\u2010to\u2010Bacteroidetes ratio and promoting beneficial bacteria such as <jats:styled-content style=\"fixed-case\">\n<jats:italic>NK4A136<\/jats:italic>\n<\/jats:styled-content>, <jats:italic>Muribaculum<\/jats:italic>, and <jats:italic>Gordonibacter<\/jats:italic>. These microbiota changes improved liver lipid metabolism and alleviated depressive symptoms. Green tea effectively mitigates depression\u2010like behavior and cognitive deficits by modulating the gut\u2010liver\u2010brain axis.<\/jats:p>","DOI":"10.1002\/ptr.8499","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T05:03:46Z","timestamp":1744866226000},"page":"2707-2723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Green Tea Ameliorates Depression\u2010Like Behavior and Cognitive Impairment Induced by High\u2010Fat Diet and Chronic Mild Stress"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0870-4796","authenticated-orcid":false,"given":"Minghao","family":"Fan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biological Fermentation Engineering of Beer Tsingtao Brewery Co. 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