{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:07:42Z","timestamp":1787620062182,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Osteoporosis, characterized by osteoclastic bone resorption, has been the focus of research. Studies implicate that reactive oxygen species (ROS) accumulate intracellularly during osteoclastogenesis. Salvianolic acid A (SAA), a compound derived from\n                    <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    , has been widely used to treat cardiovascular and cerebrovascular disorders, owing to its antioxidant and anti\u2010inflammatory properties. In this study, we investigated the therapeutic effects of SAA on osteoporotic bone loss in\u00a0vitro and in osteoporotic mice induced by ovariectomy (OVX) and explored the underpinning mechanisms. In\u00a0vitro, SAA significantly restrained osteoclastogenesis and osteoclastic resorption in a dose\u2010 and time\u2010dependent manner. SAA markedly blocked the expression of osteoclast\u2010specific genes and proteins such as NFATc1 and c\u2010Fos. Specifically, SAA reduced ROS production by enhancing the expression and nuclear translocation of nuclear factor erythroid 2\u2010related factor 2 (Nrf2) to activate HO\u20101 and catalase, with no effect on Bach1. In addition, SAA simultaneously suppressed the NF\u2010\u03baB and mitogen\u2010activated protein kinase (MAPK) signaling pathway, ultimately arresting NFATc1 expression to constrain the differentiation and function of osteoclasts. Micro\u2010CT and histological evidence demonstrated that SAA at a nontoxic dose successfully reduced bone loss induced by OVX, with fewer mature osteoclasts. These findings revealed that SAA provides a potential treatment strategy for reducing osteoclast\u2010related bone ailments, including osteoporosis.\n                  <\/jats:p>","DOI":"10.1002\/ptr.8503","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T08:21:55Z","timestamp":1754468515000},"page":"4977-4990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2\u2013HO\u20101 Pathway"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0509-8950","authenticated-orcid":false,"given":"Hao","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Xinqiao Hospital, Army Medical University  Chongqing 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