{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:25:01Z","timestamp":1789809901229,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2001,8,21]],"date-time":"2001-08-21T00:00:00Z","timestamp":998352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The fruits of <jats:italic>Ligustrum lucidum Ait.<\/jats:italic> (FLL) were fractionated into petroleum ether (FLL\u2010Pe), chloroform (FLL\u2010Ch), butanol (FLL\u2010Bu) and aqueous (FLL\u2010Aq) fractions, of which FLL\u2010Ch and FLL\u2010Bu were found to be enriched with oleanolic acid (OLA). The <jats:italic>in vivo<\/jats:italic> antioxidant activities of various FLL fractions and OLA were assessed by examining the effect on carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced hepatotoxicity in mice. Pretreatment of animals with various FLL fractions could protect against CCl<jats:sub>4<\/jats:sub>\u2010induced hepatotoxicity to a varying degree, with OLA\u2010enriched FLL\u2010Bu and FLL\u2010Ch being more potent. However, a mortality rate of 60% was observed in the FLL\u2010Ch pretreated and CCl<jats:sub>4<\/jats:sub>\u2010intoxicated mice. OLA pretreatment also produced a dose\u2010dependent protection against CCl<jats:sub>4<\/jats:sub> hepatotoxicity. The hepatoprotection afforded by FLL\u2010Bu or OLA pretreatment was associated with an enhancement of hepatic\u00adglutathione regeneration capacity (GRC). In contrast, the inability of FLL\u2010Aq pretreatment to enhance hepatic GRC resulted in a failure to prevent CCl<jats:sub>4<\/jats:sub>\u2010induced hepatic injury. The results suggest that the hepatoprotective action afforded by OLA\u2010enriched FLL\u2010Bu or OLA pretreatment may be mainly mediated by the enhancement of hepatic GRC, particularly under conditions of CCl<jats:sub>4<\/jats:sub>\u2010induced oxidative stress. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.878","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:20:09Z","timestamp":1030310409000},"page":"589-592","source":"Crossref","is-referenced-by-count":83,"title":["Hepatoprotective action of an oleanolic acid\u2010enriched extract of<i> Ligustrum lucidum<\/i> fruits is mediated through an enhancement on hepatic glutathione regeneration capacity in mice"],"prefix":"10.1002","volume":"15","author":[{"given":"T. K.","family":"Yim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. K.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. F.","family":"Pak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,8,21]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"981","article-title":"Protective effect of oleanolic acid and ursolic acid against lipid peroxidation","volume":"24","author":"Balanehru S","year":"1991","journal-title":"Biochem Int"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86093-B"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-958123"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(99)00004-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.47.290"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.69.439"},{"key":"e_1_2_1_8_1","first-page":"504","article-title":"Progress in the study of Fructus Ligustri Lucidi.","volume":"19","author":"Li ML","year":"1994","journal-title":"China J Chinese Mat Med"},{"key":"e_1_2_1_9_1","first-page":"656","volume-title":"Zhong Yao Fang Ji Xue","author":"Liang SM","year":"1991"},{"key":"e_1_2_1_10_1","first-page":"97","article-title":"Protective effect of oleanolic acid against chemical\u2010induced acute necrotic liver injury in mice","volume":"16","author":"Liu J","year":"1995","journal-title":"Acta Pharm Sin"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(94)90084-1"},{"key":"e_1_2_1_12_1","first-page":"1","volume-title":"CRC Handbook of Free Radicals and Antioxidants in Biomedicine","author":"Recknagel RO","year":"1989"},{"key":"e_1_2_1_13_1","first-page":"25S","article-title":"Glutathione depletion and susceptibility","volume":"36","author":"Reed DJ","year":"1984","journal-title":"Pharmacol Rev"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(88)90027-7"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(72)80434-4"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.20.6246"},{"key":"e_1_2_1_17_1","first-page":"497.","volume-title":"Research on Fructus Ligustri Lucidi","author":"Xiang GC","year":"1994"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.878","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T11:40:47Z","timestamp":1700307647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8,21]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["10.1002\/ptr.878"],"URL":"https:\/\/doi.org\/10.1002\/ptr.878","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8,21]]}}}