{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:57:02Z","timestamp":1759964222403},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,6,11]],"date-time":"2002-06-11T00:00:00Z","timestamp":1023753600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies were carried out to evaluate the influence of the methanol fraction of <jats:italic>Pluchea indica<\/jats:italic> Less root extract (PIRE), the dual inhibitors (BW 755C and phenidone) and vitamin on both <jats:italic>in vivo and in vitro<\/jats:italic> free radical\u2010scavenging activities, CCl<jats:sub>4<\/jats:sub>\u2010induced lipid peroxidation and the metabolism of arachidonic acid by lipoxygenase. PIRE produced significant antiinflammatory activity against glucose oxidase\u2010induced paw oedema (<jats:italic>in vivo<\/jats:italic>), inhibited hydroxyl radical and superoxide generation, lysis of erythrocytes induced by hydrogen peroxide, CCl<jats:sub>4<\/jats:sub>\u2010induced lipid peroxidation and also dioxygenase activity of lipoxygenase (both in the presence and absence of hydrogen peroxide). Significantly higher free radical\u2010scavenging activity was observed with BW 755C and phenidone compared with PIRE. However, both BW 755C and phenidone stimulated hydroxyl radical generation compared with the observed inhibitory effects of PIRE and vitamin E. 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