{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:19:30Z","timestamp":1760887170201},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,9,17]],"date-time":"2002-09-17T00:00:00Z","timestamp":1032220800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Mikania laevigata<\/jats:italic> Schultz Bip. ex Baker, <jats:italic>M. involucrata<\/jats:italic> Hook. et Arn. and <jats:italic>M. hirsutissima<\/jats:italic> DC. (Asteraceae), commonly occurring in the southern Brazilian State of Rio Grande do Sul, were submitted to biological tests to evaluate their potential antiinflammatory activity. Decoctions from the leaves and stems were analysed by the induced rat paw oedema and pleurisy models. The animals were treated orally with different decoction doses. In the induced rat paw oedema test, the animals treated with leaf decoctions from <jats:italic>M. laevigata<\/jats:italic> (200\u2009mg\/\u2009kg) and <jats:italic>M. involucrata<\/jats:italic> (50\u2009mg\/\u2009kg) presented an oedema inhibition of 81.56% and 81.67%, respectively, 3\u2005h after the administration of the phlogistic agent. Leaf decoctions from <jats:italic>M. hirsutissima<\/jats:italic> (400\u2009mg\/\u2009kg) did not show such an activity. Stem decoctions displayed lower antiinflammatory activity when compared with the same doses and response time of the leaf decoctions for all analysed species. In the pleurisy assay, leaf decoctions from <jats:italic>M. laevigata<\/jats:italic> (400\u2009mg\/\u2009kg) and <jats:italic>M. involucrata<\/jats:italic> (200\u2009mg\/\u2009kg) inhibited leukocyte migration to the pleural exudate by 28.26% and 54.35%, respectively. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.908","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T02:15:40Z","timestamp":1034129740000},"page":"519-523","source":"Crossref","is-referenced-by-count":26,"title":["Antiinflammatory investigation of some species of <i>Mikania<\/i>"],"prefix":"10.1002","volume":"16","author":[{"given":"E. S.","family":"Suyenaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Reche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. M.","family":"Farias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. E. S.","family":"Schapoval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. G. M.","family":"Chaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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