{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:05:40Z","timestamp":1790845540957,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,6,11]],"date-time":"2002-06-11T00:00:00Z","timestamp":1023753600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The hypoglycaemic activities of four water ethanol extracts (WEE) prepared from <jats:italic>Bidens pilosa<\/jats:italic> L., <jats:italic>Salvia officinalis<\/jats:italic> L., <jats:italic>Psacalium peltatum<\/jats:italic> H.B.K. (Cass) and <jats:italic>Turnera diffusa<\/jats:italic> Willd. were investigated in healthy and alloxan\u2010diabetic mice. The WEE of <jats:italic>S. officinalis<\/jats:italic> significantly reduced the blood glucose of fasting normal mice 120 (15.7%) and 240\u2005min (30.2%) after intraperitoneal administration (<jats:italic>p<\/jats:italic>\u2005&lt;\u20050.05). The WEE of <jats:italic>P. peltatum<\/jats:italic> and <jats:italic>B. pilosa<\/jats:italic> also significantly diminished glycaemia in healthy mice at 240\u2005min (19.6% and 13.8%, respectively). In mildly diabetic mice, the WEE of <jats:italic>P. peltatum<\/jats:italic> lowered the basal blood glucose level 120 (16%) and 240\u2005min (54%) after intraperitoneal administration (<jats:italic>p<\/jats:italic>\u2005&lt;\u20050.05 and <jats:italic>p<\/jats:italic>\u2005&lt;\u20050.01, respectively). The WEE of <jats:italic>B. pilosa<\/jats:italic> and <jats:italic>S. officinalis<\/jats:italic> also significantly diminished the hyperglycaemia in mildly diabetic mice at 240 mins (32.6% and 22.7%, respectively). The administration of these three extracts to animals with severe hyperglycaemia did not cause a significant decrease. The WEE of <jats:italic>T. diffusa<\/jats:italic> did not show any hypoglycaemic activity. Thus, three of the WEE studied conserved the hypoglycaemic activity originally detected in the traditional preparations of the studied antidiabetic plants. It appears that these extracts require the presence of insulin to show hypoglycaemic activity. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.914","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:29:56Z","timestamp":1033907396000},"page":"383-386","source":"Crossref","is-referenced-by-count":102,"title":["Investigation on the hypoglycaemic effects of extracts of four Mexican medicinal plants in normal and Alloxan\u2010diabetic mice"],"prefix":"10.1002","volume":"16","author":[{"given":"F. J.","family":"Alarcon\u2010Aguilar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Roman\u2010Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Flores\u2010Saenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Aguirre\u2010Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,6,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(96)01494-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(98)00020-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957902"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-1778-2_4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/13880209009082780","article-title":"Pyrrolizidine alkaloids of Senecio glabellus.","volume":"28","author":"Kapadia G","year":"1990","journal-title":"Int J Crude Drug Res"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650070302"},{"key":"e_1_2_1_8_1","first-page":"58","article-title":"Diabetes mellitus. The hypoglycaemic activity of phytosterin on alloxan diabetic rats. Tai\u2010Wan 1","volume":"66","author":"Long\u2010Lii","year":"1967","journal-title":"Hsueh Hui\u2010tsa Chih"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0944-7113(11)80059-0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(84)90054-0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0944-7113(98)80060-3"},{"key":"e_1_2_1_12_1","first-page":"59","article-title":"Hypoglycaemic effect of plants used in Mexico as antidiabetics","volume":"23","author":"Roman\u2010Ramos R","year":"1992","journal-title":"Arch Med Res"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(95)01279-M"},{"key":"e_1_2_1_14_1","first-page":"87","article-title":"Experimental study of the hypoglycaemic effect of some antidiabetic plants","volume":"22","author":"Roman\u2010Ramos R","year":"1991","journal-title":"Arch Invest Med"},{"key":"e_1_2_1_15_1","first-page":"105","article-title":"Hypoglycaemic activity of some antidiabetic plants","volume":"23","author":"Roman\u2010Ramos R","year":"1992","journal-title":"Arch Med Res"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199855020-00004"},{"key":"e_1_2_1_17_1","first-page":"6","article-title":"Detection of pyrrolizidine\u2010type alkaloids in matarique (Cacalia decomposita)","volume":"23","author":"Sullivan G","year":"1981","journal-title":"Veter Hum Toxicol"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(93)90015-W"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(90)90537-2"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.914","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T15:31:06Z","timestamp":1700321466000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1002\/ptr.914"],"URL":"https:\/\/doi.org\/10.1002\/ptr.914","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}