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Oral pretreatment with <jats:italic>Garcinia cambogia<\/jats:italic> fruit extract (1\u2005g\/kg body wt\/day) for 5, 10 or 15 days protected the gastric mucosa against the damage induced by indomethacin (20\u2005mg\/kg body wt). The volume and acidity of the gastric juice decreased in the pretreated rats. The glycoprotein levels of the gastric contents which were decreased in the untreated rats, maintained near normal levels in the pretreated rats. Protein which was elevated in the gastric juice of untreated rats, showed near normal levels in the pretreated rats. <jats:italic>Garcinia cambogia<\/jats:italic> was able to decrease the acidity and to increase the mucosal defence in the gastric areas, thereby justifying its use as an antiulcerogenic agent. 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