{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:33:46Z","timestamp":1772897626771,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,9,17]],"date-time":"2002-09-17T00:00:00Z","timestamp":1032220800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> studies were made with an alcohol extract of the seeds of <jats:italic>Mucuna pruriens<\/jats:italic> (Fabaceae) to investigate its antioxidant property. <jats:italic>In vitro<\/jats:italic> studies were carried out in rat liver homogenate to investigate the chemical interaction of various phytochemicals with different species of free radicals. The effect was also checked on iron\u2010induced lipid peroxidation, oxidation of GSH content, and its interaction with hydroxyl and superoxide radicals. There was no change on the rate of aerial oxidation of GSH content but it significantly inhibited FeSO<jats:sub>4<\/jats:sub> induced lipid peroxidation. It also inhibited the specific chemical reactions induced by superoxides and hydroxyl radicals. The removal of these species was through direct chemical interaction. An <jats:italic>in vivo<\/jats:italic> study on albino rats for 30 days showed no toxic effect up to a dose of 600\u2005mg\/kg body weight, on oral administration. There was no change in the level of TBA\u2010reactive substances, reduced glutathione content and SOD activity in the liver. The activity of serum GOT, GPT and alkaline phosphatase was also unchanged. Thus it could be concluded that the alcohol extract of the seeds of <jats:italic>M. pruriens<\/jats:italic> has an antilipid peroxidation property, which is mediated through the removal of superoxides and hydroxyl radicals. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.962","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T02:15:40Z","timestamp":1034129740000},"page":"534-538","source":"Crossref","is-referenced-by-count":25,"title":["Effect of the alcohol extract of the seeds of<i> Mucuna pruriens<\/i> on free radicals and oxidative stress in albino rats"],"prefix":"10.1002","volume":"16","author":[{"given":"Yamini B.","family":"Tripathi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil K.","family":"Upadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,9,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0810459"},{"key":"e_1_2_1_3_1","volume-title":"Indian Medicinal Plants","author":"Chopra RN","year":"1956"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05013-8"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1042\/bj1630441","article-title":"Generation of hydrogen peroxide superoxide and hydroxyl radicals during the oxidation of bihydroxyfumaric acid by peroxidase","volume":"163","author":"Halliwell B","year":"1977","journal-title":"Biochem J"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(86)90207-0"},{"key":"e_1_2_1_8_1","first-page":"29","article-title":"Hypoglycaemic effect of Glycine soja, Dolichos biflorus and Mucuna pruriens\u2010 seed diets in albino rats","volume":"2","author":"Joshi LD","year":"1970","journal-title":"Indian J Pharmacol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_10_1","first-page":"92","article-title":"Indian medicinal plants\u2010V. 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PhD thesis Banaras Hindu University India."},{"key":"e_1_2_1_21_1","first-page":"179","article-title":"Activity of bromoergocryptine, Mucuna pruriens and L\u2010DOPA in the control of hyperprolactinaemia","volume":"26","author":"Vaidya RA","year":"1978","journal-title":"Neurology (India)"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.962","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T10:08:43Z","timestamp":1696673323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1002\/ptr.962"],"URL":"https:\/\/doi.org\/10.1002\/ptr.962","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}