{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:13:16Z","timestamp":1790809996463,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Public Health Challenges"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Depression among patients with sickle cell disease (SCD) is crucial as it is often underdiagnosed and undertreated. Therefore, this study aimed to determine the prevalence of depression and to identify its determinants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study was conducted in the Bardiya district of Nepal, based on registered cases of SCD. Depression was measured using the validated Nepalese version of the Beck Depression Inventory (BDI). A random sample of 358 participants with SCD aged &gt;13 years was included in the study. Descriptive and inferential statistics were applied to sociodemographic, clinical and psychological variables. Logistic regression analysis was performed for bivariate analysis. Variables with a <jats:italic>p<\/jats:italic> value of less than 0.05 were subjected to final multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of depression was 36.31% among patients with SCD, age (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0178), education (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0178) and sociodemographic status (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0328) were strongly associated. Factors such as patients aged 40\u201349 years (adjusted odds ratio [AOR]\u00a0=\u00a03.05), complications due to SCD (AOR\u00a0=\u00a01.86) and genetic counselling group (AOR\u00a0=\u00a04.72) had higher chances of experiencing depression compared to their relative counterparts. However, patients with lower middle\u2010class economic status, who experience pain crisis, with moderate self\u2010esteem and who experience discrimination were 52%, 83%, 58% and 58% less likely to have depression compared to their respective counterparts, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Depression was prevalent in patients with SCD, and multiple sociodemographic, clinical and psychological factors were strongly associated. This warrants the urgent need for early diagnosis and treatment of depression among participants with SCD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/puh2.70010","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T09:54:43Z","timestamp":1732528483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Depression and Its Determinants Among Patients With Sickle Cell Disease: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"3","author":[{"given":"Bhuwan","family":"Dahit","sequence":"first","affiliation":[{"name":"Patan Academy of Health Sciences  Lalitpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusudan","family":"Subedi","sequence":"additional","affiliation":[{"name":"Patan Academy of Health Sciences  Lalitpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay Kumar","family":"Rajbhandari","sequence":"additional","affiliation":[{"name":"Patan Academy of Health Sciences  Lalitpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Arjyal","sequence":"additional","affiliation":[{"name":"Patan Academy of Health Sciences  Lalitpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Data Ram","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Ministry of Health and Population  Kathmandu Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5978-3762","authenticated-orcid":false,"given":"Padam Kanta","family":"Dahal","sequence":"additional","affiliation":[{"name":"School of Health, Medical and Applied Sciences Central Queensland University, Sydney Campus  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Depression and Other Common Mental Disorders: Global Health Estimates","author":"World Health Organization","year":"2017"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.23937\/2469\u20105823\/1510020"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40359\u2010021\u201000543\u20104"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.15406\/htij.2016.02.00039"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.14070"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.08.066"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44595"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojpsych.2016.63028"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/sjmms.sjmms_123_16"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3126\/njms.v4i1.24121"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.31729\/jnma.7651"},{"key":"e_1_2_12_13_1","unstructured":"C.Karki Nepali Community Burdened With High Rates Of Sickle\u2010Cell Anaemia Seek Support(Geneva:GAVI 2024) https:\/\/www.gavi.org\/vaccineswork\/nepali\u2010community\u2010burdened\u2010high\u2010rates\u2010sickle\u2010cell\u2010anemia\u2010seek\u2010support?gad_source=1&gclid=Cj0KCQjw\u20105y1BhC\u2010ARIsAAM_oKmGcHJHr8oPT1cG0VmfzGWu4jBTlaWVf5jyC9DqXeZO5vUPnLLnTCEaAk9KEALw_wcB."},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888\u2010016\u20100810\u20100"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2023.101337"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26063"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.10517"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3126\/njms.v4i1.24121"},{"key":"e_1_2_12_19_1","unstructured":"Ministry of Health and Population (MoHP) \u201cDeprived\u2010Citizen\u2010Medical\u2010Treatment\u2010Directory\u20102075. 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