{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:57:34Z","timestamp":1780088254566,"version":"3.54.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Public Health Challenges"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Despite the availability of effective biologics, rabies continues to impact several low\u2010 and middle\u2010income countries. More than 50,000 people succumb to rabies every year due to the lack of timely and appropriate post\u2010bite care. Biologics used in post\u2010exposure prophylaxis, such as rabies vaccine, rabies immune globulins, and rabies monoclonal antibodies, are not readily available and often in short supply in the developing world, especially in Asia and Africa, where rabies is endemic in domestic dog populations and poorly controlled. Moreover, many healthcare professionals in these settings have less than ideal knowledge of current post\u2010exposure prophylaxis guidelines. To combat this, we have integrated current post\u2010bite prophylaxis guidelines and accurate information about the availability of rabies biologics into an interactive, user\u2010friendly web application, ZeroRabiesApp (ZRA). Designed as a point\u2010of\u2010care tool for treating dog bite cases, ZRA generates a customized post\u2010exposure prophylaxis schedule using the user\u2010provided date of exposure. The schedule is based on the latest guidelines developed by the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC). The ZRA also provides access to the rabies biologics database that can be used to find the nearest locations where rabies biologics needed for post\u2010exposure prophylaxis are currently available. The freely available app can offer a simple, real\u2010time, and local solution to prevent human rabies deaths following potentially rabid exposures like dog bites.<\/jats:p>","DOI":"10.1002\/puh2.70030","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T03:46:13Z","timestamp":1739245573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhancing Human Post\u2010Exposure Rabies Prophylaxis in Canine Rabies Endemic Regions With an Interactive Web Solution"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4651-0116","authenticated-orcid":false,"given":"Aniruddha V.","family":"Belsare","sequence":"first","affiliation":[{"name":"Auburn University College of Forestry, Wildlife and Environment  Auburn Alabama USA"},{"name":"Auburn University College of Veterinary Medicine  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Briggs","sequence":"additional","affiliation":[{"name":"Kansas State University College of Veterinary Medicine  Manhattan Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyanendra","family":"Gongal","sequence":"additional","affiliation":[{"name":"World Health Organization, WHO Regional Office for South\u2013East Asia  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6039-1187","authenticated-orcid":false,"given":"Reeta S.","family":"Mani","sequence":"additional","affiliation":[{"name":"Department of Neurovirology National Institute of Mental Health and Neurosciences  Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Rupprecht","sequence":"additional","affiliation":[{"name":"Auburn University College of Forestry, Wildlife and Environment  Auburn Alabama USA"},{"name":"Auburn University College of Veterinary Medicine  Auburn Alabama USA"},{"name":"LYSSA LLC  Lawrenceville Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/383870"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.14.136044"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.o2284"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12668"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(22)00641\u20107"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.04.024"},{"key":"e_1_2_8_8_1","article-title":"Patients Hit as Government Hospitals Run Out of Antirabies Vaccine","volume":"378","author":"Yasmeen A.","year":"2019","journal-title":"Hindu"}],"container-title":["Public Health Challenges"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/puh2.70030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T21:38:28Z","timestamp":1743111508000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/puh2.70030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/puh2.70030"],"URL":"https:\/\/doi.org\/10.1002\/puh2.70030","archive":["Portico"],"relation":{},"ISSN":["2769-2450","2769-2450"],"issn-type":[{"value":"2769-2450","type":"print"},{"value":"2769-2450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,7]]},"assertion":[{"value":"2024-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70030"}}