{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:04:10Z","timestamp":1784268250613,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Public Health Challenges"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Hypertension (HTN) increases mortality, healthcare costs, and disability, posing a major global public health challenge and reducing health\u2010related quality of life (HRQoL). Therefore, this study aimed to assess the HRQoL and its associated factors among hypertensive patients at selected hospitals in southwest Ethiopia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A cross\u2010sectional study conducted among 385 patients in three hospitals in southwest Ethiopia (May\u2013July 2022) assessed HRQoL using the 36\u2010Item Short Form Survey (SF\u201036). Physical component summary (PCS) and mental component summary (MCS) scores were calculated separately. Linear regression analysis was used to identify factors associated with the physical and mental health summaries of HRQoL, with statistical significance set at\n p<\/jats:italic>\n \u00a0<\u00a00.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The PCS score was 70.6\u00a0\u00b1\u00a022.8, whereas the MCS score was 56.4\u00a0\u00b1\u00a012.7. Factors associated with PCS included advanced age (\n \u03b2<\/jats:italic>\n \u00a0=\u00a0\u22120.54,\n p<\/jats:italic>\n \u00a0<\u00a00.001), female sex (\n \u03b2<\/jats:italic>\n \u00a0=\u00a0\u22123.69,\n p<\/jats:italic>\n \u00a0=\u00a00.040), higher income (\n \u03b2<\/jats:italic>\n \u00a0=\u00a00.0015,\n p<\/jats:italic>\n \u00a0=\u00a00.001), larger family size (\n \u03b2<\/jats:italic>\n \u00a0=\u00a0\u22122.35,\n p<\/jats:italic>\n \u00a0<\u00a00.001), absence of comorbidity (\n \u03b2<\/jats:italic>\n \u00a0=\u00a012.6,\n p<\/jats:italic>\n \u00a0<\u00a00.001), Stage II HTN (\n \u03b2<\/jats:italic>\n \u00a0=\u00a0\u22124.59,\n p<\/jats:italic>\n \u00a0=\u00a00.047), and Stage III HTN (\n \u03b2<\/jats:italic>\n \u00a0=\u00a0\u221215.8,\n p<\/jats:italic>\n \u00a0<\u00a00.001). Factors associated with MCS included advanced age (\n \u03b2<\/jats:italic>\n \u00a0=\u00a0\u22120.42,\n p<\/jats:italic>\n \u00a0<\u00a00.001), female sex (\n \u03b2<\/jats:italic>\n \u00a0=\u00a0\u22123.40,\n p<\/jats:italic>\n \u00a0=\u00a00.007), higher income (\n \u03b2<\/jats:italic>\n \u00a0=\u00a00.0001,\n p<\/jats:italic>\n \u00a0=\u00a00.042), and Stage III HTN (\n \u03b2<\/jats:italic>\n \u00a0=\u00a0\u22127.16,\n p<\/jats:italic>\n \u00a0=\u00a00.023).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Hypertensive patients had lower HRQoL across all domains. PCS and MCS scores declined with increasing age, female sex, low income, and greater HTN severity. Targeted interventions, including comorbidity management and blood pressure control, are vital to improving their quality of life.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/puh2.70233","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:38:58Z","timestamp":1776091138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Health\u2010Related Quality of Life and Its Determinants Among Hypertensive Patients in Southwest Ethiopia: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3173-6753","authenticated-orcid":false,"given":"Tewodros","family":"Yosef","sequence":"first","affiliation":[{"name":"School of Public Health College of Medicine and Health Sciences Mizan\u2010Tepi University Mizan Teferi Ethiopia"},{"name":"School of Medicine, IMPACT The Institute for Mental and Physical Health and Clinical Translation Deakin University Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muluken","family":"Haile","sequence":"additional","affiliation":[{"name":"School of Public Health College of Medicine and Health Sciences Mizan\u2010Tepi University Mizan Teferi Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5563-1358","authenticated-orcid":false,"given":"Nigusie","family":"Shifera","sequence":"additional","affiliation":[{"name":"School of Public Health College of Medicine and Health Sciences Mizan\u2010Tepi University Mizan Teferi Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadesse","family":"Nigussie","sequence":"additional","affiliation":[{"name":"Department of Public Health College of Health Sciences Salale University Fiche Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyam Girma","family":"Sisay","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics School of Public Health Addis Ababa University Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molla Asnake","family":"Kebede","sequence":"additional","affiliation":[{"name":"School of Medicine College of Medicine and Health Sciences Mizan\u2010Tepi University Mizan Teferi Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailemelekot Bekele","family":"Kebede","sequence":"additional","affiliation":[{"name":"School of Public Health Asrat Woldeyes Health Science Campus Debre Berhan University Debre Berhan Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alemnew","family":"Destaw","sequence":"additional","affiliation":[{"name":"School of Public Health College of Medicine and Health Sciences Mizan\u2010Tepi University Mizan Teferi Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andualem","family":"Henok","sequence":"additional","affiliation":[{"name":"School of Public Health College of Medicine and Health Sciences Mizan\u2010Tepi University Mizan Teferi Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2019.05.003"},{"key":"e_1_2_14_3_1","volume-title":"Hypertension Fact Sheets","author":"World Health Organization","year":"2023"},{"key":"e_1_2_14_4_1","first-page":"1963","article-title":"Effect of Aliskiren on Cardiovascular Outcomes in Patients With Prehypertension: A Meta\u2010Analysis of Randomized Controlled Trials","volume":"9","author":"Zhang J.\u2010T.","year":"2015","journal-title":"Drug Design, Development and Therapy"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7404957"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12963-016-0091-3"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7489875"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/picr.picr_179_25"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/uro1010003"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-7625.2012.00765.x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11121-013-0437-z"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.4172\/2167-1095.1000239"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.4172\/2167-1095.1000252"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2017.00069"},{"issue":"3","key":"e_1_2_14_15_1","first-page":"262","article-title":"Determinants of Health\u2010Related Quality of Life in Patients With Hypertension","volume":"10","author":"Shah R. B.","year":"2020","journal-title":"National Journal of Physiology, Pharmacy and Pharmacology"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-833"},{"issue":"12","key":"e_1_2_14_17_1","first-page":"5573","article-title":"The Health Related Quality of Life (HRQoL) for Hypertensive Patients in Eastern Province in Saudi Arabia: Cross Sectional Study","volume":"10","author":"Alshayban D. M.","year":"2019","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-020-01598-4"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-025-03976-1"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2018-000577"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2018.05.008"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-024-06787-8"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.972378"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47567-x"},{"issue":"2","key":"e_1_2_14_25_1","first-page":"381","article-title":"Health\u2010Related Quality of Life of Patients With Type 2 Diabetes Mellitus and Hypertension in Addis Ababa","volume":"32","author":"Shimels T.","year":"2022","journal-title":"Ethiopian Journal of Health Sciences"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0268150"},{"key":"e_1_2_14_27_1","volume-title":"SF\u201036v2\u00ae Health Survey: Administrative Guide for Clinical Trial Investigators","author":"Ware J. E.","year":"2008"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S419118"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0248481"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.006"},{"issue":"7","key":"e_1_2_14_31_1","article-title":"High Blood Pressure\u2010Associated Symptoms: Insights From a Population\u2010Based Study in Pakistan","volume":"16","author":"Kidwai S.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2025.102083"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnss.2016.10.002"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-021-03055-1"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-8212-0"},{"key":"e_1_2_14_36_1","volume-title":"Social Determinants of Mental Health","author":"World Health Organization, Calouste Gulbenkian Foundation","year":"2014"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/00333549141291S206"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-023-03449-3"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1057\/s10713-021-00070-7"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/women3030033"}],"container-title":["Public Health Challenges"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/puh2.70233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/puh2.70233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/puh2.70233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:10:21Z","timestamp":1784265021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/puh2.70233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/puh2.70233"],"URL":"https:\/\/doi.org\/10.1002\/puh2.70233","archive":["Portico"],"relation":{},"ISSN":["2769-2450","2769-2450"],"issn-type":[{"value":"2769-2450","type":"print"},{"value":"2769-2450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]},"assertion":[{"value":"2025-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70233"}}