{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:19:14Z","timestamp":1789730354445,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Public Health Challenges"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Good adherence to antihypertensive medication is critical for optimal blood pressure control and reducing disease\u2010related complications. This study aimed to assess patients\u2019 medication adherence and health\u2010related quality of life (HRQoL) and explore the relationship between medication adherence and HRQoL among hypertensive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional study was carried out at the Scheer Memorial Adventist Hospital (SMAH) in Bagmati Province, Nepal, from March 2023 to June 2023. The General Medication Adherence Scale (GMAS) and the European Quality of Life\u20105 Dimensions\u20105 Levels (EQ\u20105D\u20105L) questionnaires were used to assess medication adherence and HRQoL, respectively. Logistic regression analysis was employed to explore the relationship between participants\u2019 characteristics, medication adherence levels, and HRQoL impairment across the five dimensions of EQ\u20105D\u20105L. Statistical significance was set at\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 300 patients were surveyed, of whom only 52.33% were adherent to their antihypertensive medication. Similarly, the mean (\u00b1SD) GMAS score of the participants was 25.21 (\u00b16.5), and the mean (SD) EQ index and EQ\u2010VAS scores were 0.84\u00a0\u00b1\u00a00.22 and 72.22\u00a0\u00b1\u00a011.67, respectively. The percentages of issues in various dimensions were 47.3% for mobility, 19.66% for self\u2010care, 26.66% for usual activities, 70.33% for pain\/discomfort, and 58% for anxiety\/depression. Multiple logistic regression analysis revealed that higher education attainment, longer disease duration, and enrollment to health insurance schemes were significantly associated with improve patients\u2019 medication adherence (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Participants who were adherent to prescribed medication had lower odds of reporting problems with mobility (OR 0.21, 95% CI 0.11\u20130.39;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), usual activities (OR 0.52, 95% CI 0.27\u20131.00;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.05), pain (OR 0.17, 95% CI 0.08\u20130.32;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and anxiety (OR 0.36, 95% CI 021\u20130.62;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Medication adherence was suboptimal in substantial proportion of hypertensive patients. Adherence to medication was linked to an improved HRQoL in patients with hypertension regardless of sociodemographic and clinical variables.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/puh2.70289","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T11:52:08Z","timestamp":1780314728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Medication Adherence and Health\u2010Related Quality of Life Among Hypertensive Patients in Nepal: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4104-7184","authenticated-orcid":false,"given":"Supuspa","family":"Lama","sequence":"first","affiliation":[{"name":"Department of Pharmacy Purbanchal University School of Health Sciences, Gothgaun  Sundarharaicha Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8085-9119","authenticated-orcid":false,"given":"Prasanna","family":"Dahal","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Purbanchal University School of Health Sciences, Gothgaun  Sundarharaicha Nepal"},{"name":"Chettinad School of Pharmaceutical Sciences, Chettinad Hospital and Research Institute Chettinad Academy of Research and Education  Kelambakkam Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Neupane","sequence":"additional","affiliation":[{"name":"Department of Public Health Purbanchal University School of Health Sciences, Gothgaun  Sundarharaicha Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-2806","authenticated-orcid":false,"given":"Bipindra","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Madan Bhandari Academy of Health Sciences  Hetauda Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharanidhar","family":"Baral","sequence":"additional","affiliation":[{"name":"School of Public Health and Community Medicine B.P. Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadir","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics B.P. Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagun","family":"Kharel","sequence":"additional","affiliation":[{"name":"Department of Nursing Madan Bhandari Academy of Health Sciences  Hetauda Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010013\u20100340\u20109"},{"key":"e_1_2_11_3_1","unstructured":"World Health Organization A Global Brief on Hypertension: Silent Killer Global Public Health Crisis: World Health Day 2013(WHO 2013) 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