{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:56:45Z","timestamp":1790607405743,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Public Health Challenges"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute kidney injury (AKI) represents a growing yet under\u2010recognized public health threat in Yemen, where ongoing conflict has exacerbated vulnerabilities to infectious diseases and waterborne illnesses. Sepsis and severe volume depletion\u2014secondary to diarrheal diseases such as cholera\u2014are leading contributors to AKI incidence, especially in a region with a collapsing health infrastructure and limited access to dialysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review consolidates existing evidence on the burden, causes, and outcomes of infection\u2010related and dehydration\u2010induced AKI in Yemen. It emphasizes systemic gaps in surveillance, diagnostic capacity, and treatment and suggests practical interventions for low\u2010resource, conflict\u2010affected settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This narrative review conducted a structured search of international databases and gray literature, including sources from humanitarian agencies and regional health authorities. Studies reporting on AKI incidence, etiologies, and healthcare access in Yemen from 2014 to 2024 were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The data indicate a disproportionate burden of AKI among children and internally displaced populations within cholera\u2010endemic governorates. Shortages of dialysis resources, delayed diagnoses, and underreporting collectively worsen mortality risks. Most documented AKI cases are associated with hypovolemia, systemic infections, and a deficiency in preventive measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Infection\u2010driven and dehydration\u2010related AKI are critical yet preventable causes of morbidity and mortality in Yemen. Integrating AKI prevention into diarrheal disease programs, scaling up oral rehydration and sepsis management, and strengthening community health systems are essential to mitigating renal complications and saving lives.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/puh2.70308","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:31:11Z","timestamp":1782995471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond the Battlefield: Examining Acute Kidney Injury in Yemen's Humanitarian Crisis"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8906-3873","authenticated-orcid":false,"given":"Gamal Esam Ahmed","family":"Alsakkaf","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Near East University Nicosia North Cyprus Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2021.10.51926"},{"key":"e_1_2_15_3_1","volume-title":"Health Sector in Yemen\u2013Policy Note","author":"World Bank Group","year":"2021"},{"key":"e_1_2_15_4_1","unstructured":"ReliefWeb Yemen: WHO Health Emergency Appeal 2026\u2013Yemen(ReliefWeb 2026)."},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31235-6"},{"key":"e_1_2_15_6_1","volume-title":"Yemen Bears World's Highest Cholera Burden, Deepening Humanitarian Crisis","author":"Mishra V.","year":"2024"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.17-0811"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102302"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-025-21700-z"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2023.151466"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00218-8"},{"issue":"8","key":"e_1_2_15_12_1","first-page":"OC01","article-title":"A Clinical Study of Acute Kidney Injury in Tropical Acute Febrile Illness","volume":"10","author":"Nair J. 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