{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:56:57Z","timestamp":1790607417618,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Public Health Challenges"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Signs and symptoms of tuberculosis (TB) are a result of a disturbed balance between\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      and the patient's tolerance to its pathogenic properties. Pharmacological treatments elicit the evolution of drug resistance, and there is a need to consider alternative treatment methods. We performed a statistical analysis of World Health Organization (WHO) data, combined with an analysis of old medical records, aimed at suggesting a new treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data from the WHO for all countries worldwide (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0215) on the epidemiology of all TB cases, human immunodeficiency virus (HIV)\u2010related TB, multidrug\u2010resistant TB (MDR) and extensively drug\u2010resistant TB (XDR) in 2012\u20132022 contain prevalence, success rate of treatment, mortality and numbers of failed treatments and patients lost\u2010to\u2010follow\u2010up. Data on success rates in old \u2018sanatoria treatment\u2019, widespread before the 1940s, were used to predict hypothetical success rates of drug\u2010resistant cases if sanatoria treatment were added to treatment regimes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 2012, the number of MDR and XDR cases increased faster than the total number of TB cases, as did their proportions among the total. Success rates of MDR (\u223c70%) and XDR (around 60%) treatments would hypothetically increase to around 90%, when supplemented by sanatoria treatment success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adding treatments for increasing tolerance to TB infection to the current pharmacological treatments may improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/puh2.70363","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:46:56Z","timestamp":1789526816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can Multidrug\u2010Resistant and Extensively Drug\u2010Resistant Tuberculosis be Treated More Successfully?"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5064-2990","authenticated-orcid":false,"given":"K. L.","family":"Holloway\u2010Kew","sequence":"first","affiliation":[{"name":"Deakin Institute for Mental and Physical Health and Clinical Translation (Deakin IMPACT) School of Medicine Deakin University and Barwon Health  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-2286","authenticated-orcid":false,"given":"M.","family":"Henneberg","sequence":"additional","affiliation":[{"name":"School of Medicine Adelaide University  Adelaide South Australia Australia"},{"name":"Institute of Evolutionary Medicine University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243687"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchb.2011.10.001"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-3988-4.00013-5"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1214935"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)60916\u20108"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-3879(59)80135-5"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/shm\/1.1.1"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.88.7.1105"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0021932013000527"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2023.102389"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/4570294"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.07.056"},{"key":"e_1_2_13_14_1","unstructured":"World Health Organization Global Tuberculosis Programme(World Health Organization 2025) https:\/\/www.who.int\/teams\/global\u2010tuberculosis\u2010programme\/data."},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033\u20103506(12)80028\u2010X"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02950381"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3138\/cbmh.23.2.457"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/13602365.2014.966587"},{"issue":"3","key":"e_1_2_13_19_1","first-page":"161","article-title":"Consumptive Sanatoria: Are They Worth While?","volume":"69","author":"Lawson D.","year":"1908","journal-title":"Glasgow Medical Journal"},{"key":"e_1_2_13_20_1","first-page":"185","article-title":"Anti\u2010Tuberculosis Work in Canada","volume":"37","author":"Porter G. 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