{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:56:39Z","timestamp":1790607399408,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Public Health Challenges"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Globally, cancer remains the second leading cause of premature death. Although there are existing cancer screening programs for early detection of some of the cancers, screening remains ineffective and at times difficult for the deadliest ones, as a result of which patients present in advanced stages with guarded prognoses. Recently, promising results have been found in the largest interventional study (PATHFINDER2) of Galleri test (a multi\u2010cancer early detection [MCED] test). In this article, we dive below this headline and discuss its implications for actual clinical care and what it may contribute in addressing cancer as a top public health problem.<\/jats:p>","DOI":"10.1002\/puh2.70379","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:01:52Z","timestamp":1789527712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Terminator\u2014A Blood Test for Early Detection of 50 Cancers"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-0804","authenticated-orcid":false,"given":"Abraham Fessehaye","family":"Sium","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology St Paul's Hospital Millennium Medical College  Addis Ababa Ethiopia"},{"name":"Department of Obstetrics and Gynecology King Faisal Hospital Rwanda Africa Health Sciences University  Kigali Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Don Eliseo","family":"Lucero\u2010Prisno","sequence":"additional","affiliation":[{"name":"Department of Global Health and Development, Faculty of Public Health and Policy London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33587"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-22903-9_24"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.23.00260"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2024-1013"},{"key":"e_1_2_9_9_1","unstructured":"N.Nabavizadeh \u201cSafety and Performance of a Multi\u2010Cancer Early Detection (MCED) Test in an Intended\u2010Use Population: Initial Results From the Registrational PATHFINDER 2 Study \u201d inProffered Presentation Presented at: European Society for Medical Oncology (ESMO) Annual Meeting Berlin Germany October 17\u201321 2025."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01700\u20102"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194818"}],"container-title":["Public Health Challenges"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/puh2.70379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/puh2.70379","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/puh2.70379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:07:33Z","timestamp":1790604453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/puh2.70379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/puh2.70379"],"URL":"https:\/\/doi.org\/10.1002\/puh2.70379","archive":["Portico"],"relation":{},"ISSN":["2769-2450","2769-2450"],"issn-type":[{"value":"2769-2450","type":"print"},{"value":"2769-2450","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70379"}}