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We describe the case of a 35\u2010year\u2010old woman who developed severe PH with subsequent circulatory collapse. The patient was clinically diagnosed with PTTM induced by lung adenocarcinoma harboring the c\u2010ros oncogene 1 (ROS1) rearrangement within 1\u20132 weeks, while hemodynamics were stabilized by rescue venoarterial extracorporeal membrane oxygenation support. Crizotinib, an oral tyrosine kinase inhibitor targeting anaplastic lymphoma kinase, MET, and ROS1 kinase domains dramatically resolved PH, resulting in more than 3 years of survival. Targeted gene\u2010tailored therapy with mechanical support can improve survival in PTTM.<\/jats:p>","DOI":"10.1002\/pul2.12047","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T14:26:36Z","timestamp":1643811996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Crizotinib for ROS1\u2010rearranged lung cancer and pulmonary tumor thrombotic microangiopathy under venoarterial extracorporeal membrane oxygenation"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-4881","authenticated-orcid":false,"given":"Daisetsu","family":"Aoyama","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center  Suita Japan"},{"name":"Department of Cardiovascular Medicine University of Fukui  Fukui 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Cardiovascular Medicine National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Department of Radiology National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Nishii","sequence":"additional","affiliation":[{"name":"Department of Radiology National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Asaumi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Toyofuku","sequence":"additional","affiliation":[{"name":"Department of Cardiology Japanese Red Cross Wakayama Medical Center  Wakayama 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and Cardiovascular Center  Suita Japan"},{"name":"Department of Cardiovascular Medicine Tohoku University Graduate School of Medicine  Sendai 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