{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:38:38Z","timestamp":1790678318869,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","award":["Unrestricted educational grant from Actelion"],"award-info":[{"award-number":["Unrestricted educational grant from Actelion"]}],"id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","award":["AFRM Rehabilitation Research Entry award"],"award-info":[{"award-number":["AFRM Rehabilitation Research Entry award"]}],"id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Pulmonary hypertension (PH) is characterized by progressive dyspnea, fatigue, and reduced exercise capacity. Despite medical treatment, outcomes remain poor. While exercise training is well established in patients with heart failure, it is less established in patients with PH. This single\u2010blind, randomized controlled pilot study examined the feasibility and effect of 12\u2010week outpatient exercise (multidisciplinary rehabilitation or home walking program) on hemodynamics using cardiac magnetic resonance imaging (cMRI) and right heart catheterization (RHC) in patients with pulmonary arterial hypertension (PAH), a subset of PH. Sixteen participants were randomized to either multidisciplinary outpatient rehabilitation or a home walking program for 12 weeks. Primary outcome measures were changes in right ventricular ejection fraction and stroke volume index on cMRI. Secondary outcome measures included hemodynamics on RHC, quality of life (QOL), muscle strength (handgrip and vital capacity) and 6\u2010min\u00a0walk test. This preliminary, pilot study suggests that outpatient exercise interventions may be associated with improved hemodynamic function (mean pulmonary artery wedge pressure, stroke volume, and stroke volume index), QOL (PH symptoms, depression, and anxiety), and muscular strength (vital capacity and handgrip strength) for people with PAH, but was not adequately powered to make any formal conclusions. However, our outpatient programs were feasible, safe, and acceptable to participants. Future studies are required to further explore the potential hemodynamic benefits of exercise in PAH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pul2.12069","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T12:24:34Z","timestamp":1648297474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The exercise in pulmonary arterial hypertension (ExPAH) study: A randomized controlled pilot of exercise training and multidisciplinary rehabilitation in pulmonary arterial hypertension"],"prefix":"10.1002","volume":"12","author":[{"given":"Karen S. W.","family":"Chia","sequence":"first","affiliation":[{"name":"Department of Medicine, St Vincent's Clinical School University of New South Wales  Sydney Australia"},{"name":"Department of Rehabiliation Medicine St Vincent's Hospital  Sydney New South Wales Australia"},{"name":"UNSW Rural Clinical School  Coffs Harbour New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine\u00a0T.","family":"Shiner","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Vincent's Clinical School University of New South Wales  Sydney Australia"},{"name":"Department of Rehabiliation Medicine St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Cardiology St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron\u00a0J.","family":"Holloway","sequence":"additional","affiliation":[{"name":"Department of Cardiology St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Moreyra","sequence":"additional","affiliation":[{"name":"Department of Cardiology St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Bart","sequence":"additional","affiliation":[{"name":"Department of Cardiology St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K. 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