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Schistosomiasis\u2010associated hepatosplenic disease (SchHSD) is thought to be a major risk factor for PAH development. Herein, we describe our plans for prospectively screening SchHSD subjects for clinical evidence of PAH at two major academic medical centers and national referral hospitals in Addis Ababa, Ethiopia and Lusaka, Zambia. The screening study will primarily be conducted by echocardiography, in addition to clinical assessments. Plasma samples will be drawn and banked for subsequent analysis based on preclinical animal model rationale. If successful, this study will demonstrate feasibility of conducting prospective cohort studies of SchPAH screening in schistosomiasis\u2010endemic regions of Africa, and provide initial data on clinic\u2010based disease prevalence and potential mechanistic biomarkers underlying disease pathogenesis.<\/jats:p>","DOI":"10.1002\/pul2.12072","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T10:28:41Z","timestamp":1649154521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rationale and design of a screening study to detect schistosomiasis\u2010associated pulmonary hypertension in Ethiopia and Zambia"],"prefix":"10.1002","volume":"12","author":[{"given":"Edford","family":"Sinkala","sequence":"first","affiliation":[{"name":"Hepatology Clinic, Department of Medicine University of Zambia Teaching Hospital Lusaka 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