{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:47:55Z","timestamp":1769906875901,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inhaled iloprost is an established treatment for pulmonary arterial hypertension (PAH). However, the long\u2010term hemodynamic changes that inhaled iloprost induces are unclear. Here, we retrospectively enrolled 18 patients with PAH who received inhaled iloprost as add\u2010on to oral combination therapy from December 2016 to January 2021 at our institute in Japan. We then examined the changes in hemodynamic parameters induced by iloprost in these patients during right heart catheterization (RHC). To examine the long\u2010term effects of iloprost, we repeated the RHC examination at follow\u2010up (median time to follow\u2010up, 8.5 months). During both catheterization procedures, iloprost was administered by using an I\u2010neb AAD system (Philips NV). In a comparison of pre\u2010inhalation values at the first and follow\u2010up RHCs, inhaled iloprost significantly improved mean pulmonary artery pressure (mPAP; 39.9\u2009\u00b1\u20097.8 to 32.5\u2009\u00b1\u20097.2\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.016) and pulmonary vascular resistance (PVR; 588.5\u2009\u00b1\u2009191.7 to 464.4\u2009\u00b1\u2009188.5\u2009dyn\u2009s\u2009cm<jats:sup>\u22125<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.047). During the follow\u2010up RHC, in a comparison of the pre\u2010inhalation and best recorded values out to 30\u2009min after the end of iloprost inhalation, iloprost significantly decreased mPAP (32.5\u2009\u00b1\u20097.2 to 30.0\u2009\u00b1\u20096.6\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) and PVR (457.8\u2009\u00b1\u2009181.4 to 386.2\u2009\u00b1\u2009142.8\u2009dyn\u2009s\u2009cm<jats:sup>\u22125<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.025) and significantly increased cardiac output (4.19\u2009\u00b1\u20090.91 to 4.64\u2009\u00b1\u20091.01\u2009L\/min, <jats:italic>p<\/jats:italic>\u2009=\u20090.035). Iloprost may have not only acute vasodilation effects but also long\u2010term hemodynamic benefits in PAH patients receiving combination therapy.<\/jats:p>","DOI":"10.1002\/pul2.12074","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T09:59:37Z","timestamp":1649152777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Inhaled iloprost induces long\u2010term beneficial hemodynamic changes in patients with pulmonary arterial hypertension receiving combination therapy"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8631-4734","authenticated-orcid":false,"given":"Kenichiro","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8924-1916","authenticated-orcid":false,"given":"Shiro","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsumure","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2106-8472","authenticated-orcid":false,"given":"Masahiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2461-7174","authenticated-orcid":false,"given":"Yoshihisa","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoaki","family":"Murohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-0224"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01032-2015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2014.06.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-97"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-1586"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.87"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.38.12"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.01.077"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-17-0139"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00075305"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413687"},{"key":"e_1_2_9_13_1","unstructured":"Japanese Circulation Society. Guidelines for treatment of pulmonary hypertension.\u00a0https:\/\/www.jcirc.or.jp\/cms\/wpcontent\/uploads\/2020\/02\/JCS2017_fukuda_h.pdf(2017). 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