{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:07:36Z","timestamp":1787843256672,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":68,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014926","name":"Acceleron","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014926","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatment for pulmonary arterial hypertension (PAH) has evolved over the past decade, including approval of new medications and growing evidence to support earlier use of combination therapy. Despite these changes, few studies have assessed real\u2010world treatment patterns, healthcare resource utilization (HCRU), and costs among people with PAH using recent data. We conducted a retrospective cohort study using administrative claims from the HealthCore Integrated Research Database\u00ae. Adult members with claims for a PAH diagnosis, right heart catheterization, and who initiated PAH treatment (index date) between October 1, 2015 and November 30, 2020 were identified. Members had to be continuously enrolled in the health plan for 6\u2009months before the index date (baseline) and \u226530\u2009days after. Treatment patterns, HCRU, and costs were described. A total of 843 members with PAH (mean age 62.3\u2009years, 64.2% female) were included. Only 21.0% of members received combination therapy as their first\u2010line treatment, while most members (54.6%) received combination therapy as second\u2010line treatment. All\u2010cause HCRU remained high after treatment initiation with 58.0% of members having \u22651 hospitalization and 41.3% with \u22651 emergency room visit. Total all\u2010cause costs declined from $15,117 per patient per month at baseline to $14,201 after treatment initiation, with decreased medical costs ($14,208 vs. $6,349) more than offsetting increased pharmacy costs ($909 vs. $7,852). In summary, despite growing evidence supporting combination therapy, most members with PAH initiated treatment with monotherapy. Total costs decreased following treatment, driven by a reduction in medical costs even with increases in pharmacy costs.<\/jats:p>","DOI":"10.1002\/pul2.12090","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T09:00:42Z","timestamp":1651741242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Real\u2010world treatment patterns, healthcare resource utilization, and cost among adults with pulmonary arterial hypertension in the United States"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3889-7138","authenticated-orcid":false,"given":"Lia N.","family":"Pizzicato","sequence":"first","affiliation":[{"name":"HealthCore Inc. Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-729X","authenticated-orcid":false,"given":"Vijay R.","family":"Nadipelli","sequence":"additional","affiliation":[{"name":"Acceleron Pharma Inc., a wholly owned subsidiary of Merck Sharp &amp; Dohme Corp. Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Governor","sequence":"additional","affiliation":[{"name":"HealthCore Inc. Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Mao","sequence":"additional","affiliation":[{"name":"Acceleron Pharma Inc., a wholly owned subsidiary of Merck Sharp &amp; Dohme Corp. Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Lanes","sequence":"additional","affiliation":[{"name":"HealthCore Inc. 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