{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:59:55Z","timestamp":1776131995634,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":61,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years, the treatment of pulmonary arterial hypertension (PAH) has gradually increased, including new drugs and surgical methods, the mortality rate of PAH patients has significantly decreased, and the average survival rate has significantly improved. However, there was no obvious improvement in sexual health, mental health, and quality of life (QoL) in patients with PAH.\u00a0Although an important dimension of QoL, little is known about sexual health and sexual health\u2010related QoL\u00a0of patients with PAH in China. In this study, the female sexual function index (FSFI)\u00a0scale, the Symptom Checklist\u201090 (SCL\u201090), and emPHasis\u201010 were used to evaluate PAH associated with congenital heart disease (CHD\u2010PAH) patients\u2019 sexual function, mental health, and QoL. The score of sexual function in female CHD\u2010PAH patients ranged from 4.40 to 34.80 points, and the average score was 26.80 (19.00\u201327.80) points. The detection rate of sexual dysfunction was 48.30%. The FSFI\u00a0score of all dimensions of the sexual dysfunction group was significantly lower than that of the nonsexual dysfunction group. In addition, the scores of SCL\u201090 and emPHasis\u201010 were significantly higher than that of the nonsexual dysfunction group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The sexual function was negatively correlated with mental health (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.58,\u00a0<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and QoL (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.62,\u00a0<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) in female CHD\u2010PAH patients. The sexual function of female patients with CHD\u2010PAH is not optimistic. Sexual health may impact mental health and overall QoL in female PAH patients. Reasonable intervention measures should be taken to improve their sexual health, so as to improve their overall QoL.<\/jats:p>","DOI":"10.1002\/pul2.12164","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T18:46:40Z","timestamp":1669315600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relationships between sexual function, mental health, and quality of life of female patients with pulmonary arterial hypertension associated with congenital heart disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9975-7577","authenticated-orcid":false,"given":"Sisi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Clinical Nursing Teaching and Research Section The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Clinical Nursing Teaching and Research Section The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingzhi","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinical Nursing Teaching and Research Section The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Clinical Nursing Teaching and Research Section The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0063-2015"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15016"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2021.06.036"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01904-2018"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2016.04.001"},{"issue":"15","key":"e_1_2_12_9_1","first-page":"4983","article-title":"Quality of life of patients with pulmonary arterial hypertension: a meta\u2010analysis","volume":"25","author":"Sarzy\u0144ska K","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.14247"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00005713"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-022-02284-w"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202106-692OC"},{"issue":"2","key":"e_1_2_12_14_1","first-page":"202","article-title":"Association between health behavior and QoL in patients with pulmonary arterial hypertension","volume":"22","author":"Cui M","year":"2014","journal-title":"Chin J Chronic Dis\u00a0Prev\u00a0Control"},{"issue":"3","key":"e_1_2_12_15_1","first-page":"498","article-title":"Effect of social support on QoL in patients with pulmonary arterial hypertension","volume":"28","author":"Liang B","year":"2017","journal-title":"Hainanj Med"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.01.868"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00127113"},{"issue":"5","key":"e_1_2_12_18_1","first-page":"396","article-title":"Evaluation of psychometric characteristics of the Chinese version of pulmonary arterial hypertension disease specific scale","volume":"32","author":"Chen YX","year":"2017","journal-title":"J\u00a0Nurs\u00a0Training"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00124-2020"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2017.12.004"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S147173"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2018.04.002"},{"issue":"4","key":"e_1_2_12_23_1","first-page":"3124","article-title":"Anxiety and depression in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: results from a Chinese survey","volume":"19","author":"Zhou X","year":"2020","journal-title":"Exp Ther Med"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-062564"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-104"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.667602"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx426"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045894018788277"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202204-322ED"},{"issue":"11","key":"e_1_2_12_30_1","first-page":"1081","article-title":"Current status of female sexual function index in use","volume":"2","author":"Li Q","year":"2014","journal-title":"China Rehabil\u00a0Theory Pract"},{"issue":"2","key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"066\u201071","DOI":"10.1055\/s-0037-1598603","article-title":"Climacteric symptoms and sexual dysfunction: association between the Blatt\u2013Kupperman Index and the Female Sexual Function Index","volume":"39","author":"Cruz E","year":"2017","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"10","key":"e_1_2_12_32_1","first-page":"745","article-title":"Analysis of symptom Self\u2010rating Scale (SCL\u201090) for female medical staff","volume":"36","author":"Wang ZH","year":"2018","journal-title":"Chin\u00a0J\u00a0Occup\u00a0Dis"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2021.04.018"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1086\/682230"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12014"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-020-1625-7"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/00926230802096234"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01677.x"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03812-7"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.08.011"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.20471\/acc.2018.57.01.18"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.12164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pul2.12164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.12164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T23:07:47Z","timestamp":1692313667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.12164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/pul2.12164"],"URL":"https:\/\/doi.org\/10.1002\/pul2.12164","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2022-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12164"}}