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Pulmonary hypertension (PH) is defined by an elevated mean pulmonary artery pressure &gt;20\u2009mmHg measured during right heart catheterization. Echocardiography\u2010diagnosed PH is relatively common in patients with MM and has been associated with increased mortality, morbidity, and poor stem cell transplant outcomes. PH in patients with MM (PH\u2010MM) is usually multifactorial in origin. MM disease\u2010specific factors, host comorbidities, and treatment\u2010related adverse effects are the key factors for the development of PH\u2010MM. Pragmatically, patients with PH\u2010MM can be grouped into either (i) PH in patients with a new diagnosis of MM or (ii) PH that develops or worsens along the way of MM treatment. In the latter group, drug\u2010induced PH, venous thromboembolism, pulmonary veno occlusive disease, and cardiotoxicity should be considered as possible causes. PH\u2010MM should be evaluated and managed in a multidisciplinary setting. 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