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We extracted clinical data from patients who underwent right heart catheterizations (RHC)\u00a0on two separate occasions. Ipc\u2010PH was defined as mean pulmonary pressure\u2009&gt;20\u2009mmHg, pulmonary capillary wedge pressure\u2009&gt;15\u2009mmHg, and pulmonary vascular resistance (PVR)\u2009&lt;\u20093 WU. Progression to Cpc\u2010PH\u00a0required an increase in PVR to\u2009\u22653 WU. We performed a retrospective cohort study with repeated assessments comparing subjects that progressed to Cpc\u2010PH\u00a0to subjects that remained with Ipc\u2010PH.\u00a0Of 153 patients with Ipc\u2010PH\u00a0at baseline who underwent a repeat RHC after a median of 0.7 years (IQR\u00a00.2, 2.1), 33% (50\/153) had developed Cpc\u2010PH.\u00a0In univariate analysis comparing the two groups at baseline, body mass index (BMI)\u00a0and right atrial pressure were lower, while the prevalence of moderate or worse mitral regurgitation (MR)\u00a0was higher among those who progressed. In age\u2010 and sex\u2010adjusted multivariable analysis, only BMI (OR\u00a00.94, 95% CI 0.90\u20130.99, <jats:italic>p<\/jats:italic>\u2009=\u20090.017, <jats:italic>C<\/jats:italic>\u2009=\u20090.655) and moderate or worse MR (OR\u00a03.00, 95% CI 1.37\u20136.60, <jats:italic>p<\/jats:italic>\u2009=\u20090.006, <jats:italic>C<\/jats:italic>\u2009=\u20090.654) predicted progression, but with poor discriminatory power. This study suggests that clinical features alone cannot distinguish patients at risk for development of Cpc\u2010PH and support the need for molecular and genetic studies to identify biomarkers of progression.<\/jats:p>","DOI":"10.1002\/pul2.12249","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T02:11:52Z","timestamp":1686881512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical features do not identify risk of progression from isolated postcapillary pulmonary hypertension to combined pre\u2010 and postcapillary pulmonary hypertension"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8026-7842","authenticated-orcid":false,"given":"Gautam","family":"Babu","sequence":"first","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Annis","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonah D.","family":"Garry","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Freiberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R.","family":"Hemnes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan L.","family":"Brittain","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Vanderbilt University Medical Center Nashville Tennessee USA"},{"name":"Division of Cardiovascular Medicine, Vanderbilt Translational and Clinical Research Center Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.06.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201503-0529OC"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.942"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.05.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.192"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2021.10.002"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-020-01671-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7056360"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29526"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.12.078"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2019.07.547"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1067"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.051540"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.033"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-1653"},{"issue":"1","key":"e_1_2_11_18_1","article-title":"Pulmonary 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