{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:01Z","timestamp":1753870141492,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":72,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The percentage cross\u2010sectional area of the lung under five (%CSA<jats:sub>&lt;5<\/jats:sub>) is the percentage of pulmonary vessels with &lt;5\u2009mm<jats:sup>2<\/jats:sup> area relative to the total lung area on computed tomography (CT). The extent that %CSA<jats:sub>&lt;5<\/jats:sub> is related to pulmonary hemodynamics in patients with chronic thromboembolic pulmonary hypertension (CTEPH) is unclear, as is the effect of pulmonary endarterectomy (PEA) on %CSA<jats:sub>&lt;5<\/jats:sub>. Therefore, we aimed to evaluate the clinical significance of %CSA<jats:sub>&lt;5<\/jats:sub> in patients with CTEPH. We studied 98 patients (64 females, mean age 62.5\u2009\u00b1\u200911.9 years), who underwent CT with %CSA<jats:sub>&lt;5<\/jats:sub> measurement and right heart catheterization (RHC). Patients were classified into groups based on eligibility for PEA. We compared the %CSA<jats:sub>&lt;5<\/jats:sub> with pulmonary hemodynamics measured by RHC in various groups. In 38 patients who underwent PEA, the relationship between %CSA<jats:sub>&lt;5<\/jats:sub> and pulmonary hemodynamics was also evaluated before and after PEA. Significant correlations between %CSA<jats:sub>&lt;5<\/jats:sub> and pulmonary vascular resistance, and compliance, and pulmonary artery pulse pressure were observed in all patients. Pulmonary hemodynamics in the patients who underwent or were eligible for PEA showed a significant correlation with %CSA<jats:sub>&lt;5<\/jats:sub>. Additionally, %CSA<jats:sub>&lt;5<\/jats:sub> was significantly lower in the postoperative than in the preoperative group. There was no correlation between changes in %CSA<jats:sub>&lt;5<\/jats:sub> and pulmonary hemodynamics before and after PEA. Furthermore, %CSA<jats:sub>&lt;5<\/jats:sub> did not correlate significantly with prognosis. %CSA<jats:sub>&lt;5<\/jats:sub> may reflect pulmonary hemodynamics in CTEPH with central thrombosis. Furthermore, %CSA<jats:sub>&lt;5<\/jats:sub> was reduced by PEA postoperatively. However, %CSA<jats:sub>&lt;5<\/jats:sub> is not a prognostic indicator, its clinical usefulness in CTEPH patients is limited, and further validation is required.<\/jats:p>","DOI":"10.1002\/pul2.12287","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T07:09:55Z","timestamp":1694416195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical significance of lung cross\u2010sectional area measured by computed tomography in chronic thromboembolic pulmonary hypertension: The correlation with pulmonary hemodynamics and the limitations"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-7407","authenticated-orcid":false,"given":"Ayaka","family":"Kuriyama","sequence":"first","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6759-2026","authenticated-orcid":false,"given":"Hajime","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University  Chiba Japan"},{"name":"Health Professional Development Center Chiba University Hospital  Chiba Japan"},{"name":"Department of Medical Education, Graduate School of Medicine Chiba University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University  Chiba Japan"},{"name":"Department of Respirology Chibaken Saiseikai Narashino Hospital  Narashino Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University  Chiba Japan"},{"name":"Department of Respirology Chibaken Saiseikai Narashino Hospital  Narashino Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Sekine","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Shigeta","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichiro","family":"Sakao","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2123-029X","authenticated-orcid":false,"given":"Keiichi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goro","family":"Matsumiya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University  Chiba Japan"},{"name":"Department of Respirology Chibaken Saiseikai Narashino Hospital  Narashino Japan"},{"name":"Pulmonary Hypertension Center Chibaken Saiseikai Narashino Hospital  Narashino Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Respirology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.14797\/ICHN7633"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01915-2018"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200605-113LR"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200908-1189OC"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2009.07.022"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.09.010"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2013.02.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-88-0010"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.174.2.1740509"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719110376545"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.054"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810120604"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0769"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S177638"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0112-2016"},{"key":"e_1_2_11_18_1","article-title":"Chronic thromboembolic pulmonary hypertension","volume":"148","author":"Opitz I","year":"2018","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.5.1441"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.12287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T12:12:18Z","timestamp":1709813538000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.12287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1002\/pul2.12287"],"URL":"https:\/\/doi.org\/10.1002\/pul2.12287","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"type":"print","value":"2045-8940"},{"type":"electronic","value":"2045-8940"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2023-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12287"}}