{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:14:28Z","timestamp":1791951268595,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pulm. circ."],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypoxia pulmonary hypertension (PH) belongs to the third major category in PH classification. Chronic obstructive pulmonary disease (COPD) is a common cause of hypoxia PH. Low serum vitamin D concentration is considered to be a possible risk factor for chronic lung disease; epidemiological studies have found that vitamin D deficiency increases pulmonary artery pressure. Therefore, this study aimed to explore the role of vitamin D levels in COPD and chronic hypoxic PH. This retrospective study selected three groups of people as research subjects, including: Group N: normal control group (people without any chronic lung disease or PH); Group C: patients with COPD, but without PH; Group C\u2009+\u2009PH: patients with COPD and PH. Vitamin D levels and pulmonary artery pressure were observed in the three groups. Vitamin D levels of the three groups showed statistical differences in every pairwise comparison; the vitamin D level of Group C (20.27\u2009ng\/mL) was lower than Group N (23.48\u2009ng\/mL), Group C\u2009+\u2009PH was the lowest (14.92\u2009ng\/mL). The levels of vitamin D in the three groups in this study were generally low. Vitamin D is negatively correlated with pulmonary artery systolic blood pressure. Low vitamin D levels may have a certain relationship with the occurrence and development of COPD. Further reductions in vitamin D levels may influence the development of PH in COPD.<\/jats:p>","DOI":"10.1002\/pul2.12294","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:43:28Z","timestamp":1696484608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The role of vitamin D in chronic obstructive pulmonary disease with pulmonary hypertension"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6859-6088","authenticated-orcid":false,"given":"Mengxi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1","article-title":"Chinese guidelines for diagnosis and treatment of pulmonary hypertension (2021 edition)","volume":"101","author":"Zhai ZG","year":"2021","journal-title":"Chin Med J"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000243584.45145.3f"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.01.031"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1678S"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.560"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200808-1361OC"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2012.04.006"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02359.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.14712\/23362936.2014.17"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-1011-7"},{"issue":"6","key":"e_1_2_12_12_1","first-page":"890","article-title":"Analysis of echocardiographic characteristics and clinical significance in patients with pulmonary hypertension","volume":"11","author":"Wei FX","year":"2016","journal-title":"Intern Med"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12564"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2022.01.029"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0770-4"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70255-3"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01804-2016"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12010130"},{"key":"e_1_2_12_19_1","first-page":"1","article-title":"Effectiveness and safety of vitamin D in relation to bone health","volume":"158","author":"Cranney A","year":"2007","journal-title":"Evid Rep Technol Assess"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201110-1868OC"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004817"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.5543\/tkda.2022.21024"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33248-7"}],"container-title":["Pulmonary Circulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pul2.12294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T19:10:49Z","timestamp":1705086649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pul2.12294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/pul2.12294"],"URL":"https:\/\/doi.org\/10.1002\/pul2.12294","archive":["Portico"],"relation":{},"ISSN":["2045-8940","2045-8940"],"issn-type":[{"value":"2045-8940","type":"print"},{"value":"2045-8940","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"2023-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12294"}}